Efficacy and safety of infliximab in treating patients with ulcerative colitis: Experiences from a single medical center in southern China

Objective This study aimed to evaluate the efficacy including the patients' response rates to infliximab (IFX) therapy, relapse rates after IFX‐induced clinical remission, and the safety of IFX in Chinese patients with ulcerative colitis (UC) from a single center in southern China and to identi...

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Bibliographic Details
Published in:Journal of digestive diseases 2014-09, Vol.15 (9), p.483-490
Main Authors: Zhou, You Lian, Xie, Shan, Wang, Pu, Zhang, Ting, Lin, Min Yi, Tan, Jia Sheng, Zhi, Fa Chao, Jiang, Bo, Chen, Ye
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anti-Inflammatory Agents, Non-Steroidal - adverse effects
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Antibodies, Monoclonal - adverse effects
Antibodies, Monoclonal - therapeutic use
China
Colitis, Ulcerative - drug therapy
Drug Evaluation - methods
drug-related side effects and adverse reactions
Female
Gastrointestinal Agents - adverse effects
Gastrointestinal Agents - therapeutic use
Humans
Inflammatory bowel disease
Infliximab
Male
Middle Aged
Recurrence
Remission Induction
Retrospective Studies
Risk Factors
Treatment Outcome
ulcerative colitis
Young Adult
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Summary:Objective This study aimed to evaluate the efficacy including the patients' response rates to infliximab (IFX) therapy, relapse rates after IFX‐induced clinical remission, and the safety of IFX in Chinese patients with ulcerative colitis (UC) from a single center in southern China and to identify the risk factors associated with disease relapse. Methods Medical records of Chinese UC patients who were diagnosed and received at least two infusions of IFX at Nanfang Hospital, Southern Medical University from July 2010 to February 2013 were retrospectively reviewed. Primary outcomes were regarded as the clinical response and relapse rates during 30 weeks after the initiation of the therapy. Overall adverse events and relapse‐related risk factors were also evaluated. Results A total of 24 UC patients was finally included. The clinical response and remission rates were 83.3% and 50.0% at week 2, 91.3% and 73.9% at week 6 and 84.6% and 61.5% by week 30. Relapse after IFX‐induced clinical remission was initiated at the fourth infusion. The relapse rate was 29.4% at week 14, 25.0% at week 22 and 20.0% at week 30, respectively. After 30 weeks only 33.3% remained on maintenance therapy. IFX‐associated adverse events occurred in 29.2% of patients, with most being mild and transient. Patients with distal or extensive colitis were at a higher risk of relapse than those with ulcerative proctitis. Conclusions IFX is effective and safe in treating Chinese UC patients, although long‐term remission is hard to achieve. Distal or extensive colitis may be an independent predictor of disease relapse.
ISSN:1751-2972
1751-2980
DOI:10.1111/1751-2980.12161