Larger A1/M1 Diameter Ratio Predicts Embolic Anterior Cerebral Artery Territorial Stroke

BACKGROUND AND PURPOSE—In contrast to middle cerebral artery territory strokes, anterior cerebral artery strokes (ACAS) occur rarely. The low frequency of ACAS, in relation to middle cerebral artery territory strokes, may be explained by differences in ACA and middle cerebral artery anatomy influenc...

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Bibliographic Details
Published in:Stroke (1970) 2014-09, Vol.45 (9), p.2798-2800
Main Authors: Shoamanesh, Ashkan, Masoud, Hesham, Furey, Katrina, Duerfeldt, Kaylyn, Lau, Helena, Romero, Jose R, Pikula, Aleksandra, Teal, Philip, Nguyen, Thanh N, Kase, Carlos S, Babikian, Viken L
Format: Article
Language:English
Subjects:
Aged
Anterior Cerebral Artery - anatomy & histology
Anterior Cerebral Artery - diagnostic imaging
Anterior Cerebral Artery - physiopathology
Biological and medical sciences
Carotid Artery, Internal - anatomy & histology
Carotid Artery, Internal - diagnostic imaging
Carotid Artery, Internal - physiopathology
Cerebral Angiography
Cross-Sectional Studies
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hemodynamics
Humans
Infarction, Anterior Cerebral Artery - diagnostic imaging
Infarction, Anterior Cerebral Artery - physiopathology
Magnetic Resonance Angiography
Male
Medical sciences
Middle Aged
Nervous system (semeiology, syndromes)
Neurology
Odds Ratio
Retrospective Studies
Thromboembolism
Vascular diseases and vascular malformations of the nervous system
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Summary:BACKGROUND AND PURPOSE—In contrast to middle cerebral artery territory strokes, anterior cerebral artery strokes (ACAS) occur rarely. The low frequency of ACAS, in relation to middle cerebral artery territory strokes, may be explained by differences in ACA and middle cerebral artery anatomy influencing their respective flow-directed embolism rates. We aimed to determine whether variability in ACA anatomy, and in particular A1 segment diameter, is associated with embolic ACAS. METHODS—Consecutive patients admitted to Boston Medical Center with embolic ACAS were reviewed. Ipsilateral and contralateral A1 diameters, M1 diameters, and terminal internal carotid artery bifurcation angles were measured from computed tomographic angiography and MRI angiography images. We compared these measurements between cases of ACAS and consecutive cases of embolic middle cerebral artery territory strokes. RESULTS—The study comprised 55 individuals (27 ACAS, 28 middle cerebral artery territory strokes) with mean age of 69 years. In multivariate regression analysis, larger ipsilateral A1 diameters (odds ratio per 1 mm increment8.5; 95% confidence interval, 1.4–53.3) and ipsilateral A1/M1 diameter ratio (odds ratio per 10% increment1.8; 95% confidence interval, 1.2–2.9) were associated with ACAS, whereas larger ipsilateral M1 diameters was protective for ACAS (odds ratio per 1 mm increment0.8; 95% confidence interval, 0.0–0.9). CONCLUSIONS—Larger ipsilateral A1 diameters and A1/M1 diameter ratio are associated with embolic ACAS. These findings suggest that A1 diameters and M1 diameters are important in determining the path of emboli that reach the terminal internal carotid artery.
ISSN:0039-2499
1524-4628
DOI:10.1161/STROKEAHA.114.005672