Lactobacillus plantarum IFPL935 impacts colonic metabolism in a simulator of the human gut microbiota during feeding with red wine polyphenols

The colonic microbiota plays an important role in the bioavailibility of dietary polyphenols. This work has evaluated the impact on the gut microbiota of long-term feeding with both a red wine polyphenolic extract and the flavan-3-ol metabolizer strain Lactobacillus plantarum IFPL935. The study was...

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Bibliographic Details
Published in:Applied microbiology and biotechnology 2014-08, Vol.98 (15), p.6805-6815
Main Authors: Barroso, E, Van de Wiele, T, Jiménez-Girón, A, Muñoz-González, I, Martín-Alvarez, P. J, Moreno-Arribas, M. V, Bartolomé, B, Peláez, C, Martínez-Cuesta, M. C, Requena, T
Format: Article
Language:English
Subjects:
Acids
Alcohol
Analysis
Antimicrobial agents
Applied Microbial and Cell Physiology
Bacteria
Bacteria - genetics
Bacteria - isolation & purification
Bacteria - metabolism
Bacteroides
Bifidobacterium
Biomedical and Life Sciences
Biotechnology
butyric acid
Clostridium coccoides
Colon
Colon - metabolism
Colon - microbiology
Digestive system
Enterobacteriaceae
Eubacterium rectale
Experiments
Fermentation
flavanols
Gastrointestinal Tract - metabolism
Gastrointestinal Tract - microbiology
Humans
ingredients
intestinal microorganisms
lactic acid
Lactobacillus
Lactobacillus plantarum
Lactobacillus plantarum - physiology
Life Sciences
Metabolism
Metabolites
microbial ecology
Microbial Genetics and Genomics
Microbiology
Microbiota
Microbiota (Symbiotic organisms)
Models, Biological
plate count
Polyphenols
Polyphenols - metabolism
Probiotics - metabolism
propionic acid
proteolysis
red wines
Small intestine
Studies
Vitaceae
Wine - analysis
Wines
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Summary:The colonic microbiota plays an important role in the bioavailibility of dietary polyphenols. This work has evaluated the impact on the gut microbiota of long-term feeding with both a red wine polyphenolic extract and the flavan-3-ol metabolizer strain Lactobacillus plantarum IFPL935. The study was conducted in the dynamic Simulator of the Human Intestinal Microbial Ecosystem (SHIME). The feeding of the gut microbiota model with red wine polyphenols caused an initial decrease in the counts of total bacteria in the ascending colon (AC), with Bacteroides, Clostridium coccoides/Eubacterium rectale and Bifidobacterium being the most affected bacterial groups. The bacterial counts recovered to initial numbers faster than the overall microbial fermentation and proteolysis, which seemed to be longer affected by polyphenols. Addition of L. plantarum IFPL935 helped to promptly recover total counts, Lactobacillus and Enterobacteriaceae and led to an increase in lactic acid formation in the AC vessel at the start of the polyphenol treatment as well as butyric acid in the transverse (TC) and descending (DC) vessels after 5 days. Moreover, L. plantarum IFPL935 favoured the conversion in the DC vessel of monomeric flavan-3-ols and their intermediate metabolites into phenylpropionic acids and in particular 3-(3′-hydroxyphenyl)propionic acid. The results open the possibilities of using L. plantarum IFPL935 as a food ingredient for helping individuals showing a low polyphenol-fermenting metabotype to increase their colonic microbial capacities of metabolizing dietary polyphenols.
ISSN:0175-7598
1432-0614
DOI:10.1007/s00253-014-5744-1