Ethanol versus heparin locks for the prevention of central venous catheter-associated bloodstream infections: a randomized trial in adult haematology patients with Hickman devices

Summary The effectiveness of ethanol locks for prevention of central venous catheter (CVC)-associated bloodstream infection (CLABSI) in adult haematology patients has not been thoroughly evaluated. This study aimed to compare prospectively heparinized saline with 70% ethanol locks using 2 h dwell ti...

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Bibliographic Details
Published in:The Journal of hospital infection 2014-09, Vol.88 (1), p.48-51
Main Authors: Worth, L.J, Slavin, M.A, Heath, S, Szer, J, Grigg, A.P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Anticoagulants - pharmacology
Bacterial diseases
Bacterial sepsis
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Bloodstream infection
Bone marrow transplantation
Bone marrow, stem cells transplantation. Graft versus host reaction
Catheter-Related Infections - prevention & control
Central venous catheter
Central Venous Catheters - microbiology
Disinfectants - pharmacology
Ethanol - pharmacology
Ethanol lock
Female
Haematology
Hematologic Neoplasms - complications
Heparin - pharmacology
Human bacterial diseases
Humans
Infectious Disease
Infectious diseases
Male
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Prophylaxis
Prospective Studies
Sepsis - prevention & control
Transfusions. Complications. Transfusion reactions. Cell and gene therapy
Treatment Outcome
Young Adult
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Summary:Summary The effectiveness of ethanol locks for prevention of central venous catheter (CVC)-associated bloodstream infection (CLABSI) in adult haematology patients has not been thoroughly evaluated. This study aimed to compare prospectively heparinized saline with 70% ethanol locks using 2 h dwell time in patients with tunnelled CVCs. In saline ( N  = 43) and ethanol ( N  = 42) groups, CLABSI rates were 6.0 [95% confidence interval (CI): 3.4–9.8] and 4.1 (95% CI: 1.9–7.7) per 1000 CVC days, respectively ( P  = 0.42). In the ethanol group, two exit-site infections and one tunnel/pocket infection were observed. Reduction in device-associated infection was not achieved with prophylactic 70% ethanol locks in patients with haematological malignancy and tunnelled CVCs.
ISSN:0195-6701
1532-2939
DOI:10.1016/j.jhin.2014.06.007