Six-month follow-up study of health markers of nanomaterials among workers handling engineered nanomaterials

Abstract The aim of this study was to identify the health hazards and possible exposure surveillance markers of workers exposed to nanoparticles during manufacturing and application in comparison to a group of unexposed workers. For this longitudinal study, we recruited 158 nanomaterial-handling wor...

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Published in:Nanotoxicology 2014-08, Vol.8 (S1), p.100-110
Main Authors: Liao, Hui-Yi, Chung, Yu-Teh, Lai, Ching-Huang, Wang, Shu-Li, Chiang, Hung-Che, Li, Lih-Ann, Tsou, Tsui-Chun, Li, Wan-Fen, Lee, Hui-Ling, Wu, Wei-Te, Lin, Ming-Hsiu, Hsu, Jin-Huei, Ho, Jiune-Jye, Chen, Chiou-Jong, Shih, Tung-Sheng, Lin, Chin-Chi, Liou, Saou-Hsing
Format: Article
Language:English
Subjects:
Antioxidant enzymes
cardiovascular disease
Follow-Up Studies
follow-up study
genotoxicity
health markers
Humans
lung inflammation
nanomaterials
Nanostructures
Occupational Exposure
oxidative stress
pulmonary function
Taiwan
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Summary:Abstract The aim of this study was to identify the health hazards and possible exposure surveillance markers of workers exposed to nanoparticles during manufacturing and application in comparison to a group of unexposed workers. For this longitudinal study, we recruited 158 nanomaterial-handling workers and 104 non-exposed workers from 14 manufacturing plants in Taiwan (baseline). Among them, 124 nanomaterial-handling workers and 77 unexposed workers were monitored 6 months later. We investigated pulmonary and cardiovascular disease markers, inflammation and oxidative stress markers, antioxidant enzymes and genotoxicity markers. Antioxidant enzymes (superoxide dismutase, glutathione peroxidase) and cardiovascular markers (vascular cell adhesion molecule, paraoxonase) were significantly associated with nanomaterial-handling during the 6-month follow-up period. In addition, the small airway damage marker (Clara cell protein 16) and lung function test parameters were also significantly associated with handling nanomaterials. The study markers and lung function tests are possible markers that could be useful for surveillance of nanomaterial-handling workers.
ISSN:1743-5390
1743-5404
DOI:10.3109/17435390.2013.858793