Determinants of health-related quality of life in people with Parkinson’s disease: a path analysis

Purpose To identify the demographic factors, impairments and activity limitations that contribute to health-related quality of life (HRQOL) in people with idiopathic Parkinson’s disease (PD). Method Two hundred and ten individuals with idiopathic PD who participated in the baseline assessment of a r...

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Bibliographic Details
Published in:Quality of life research 2013-09, Vol.22 (7), p.1543-1553
Main Authors: Soh, Sze-Ee, McGinley, Jennifer L., Watts, Jennifer J., Iansek, Robert, Murphy, Anna T., Menz, Hylton B., Huxham, Frances, Morris, Meg E.
Format: Article
Language:English
Subjects:
Activities of Daily Living
Activity limitations
Aged
Aged, 80 and over
Australia - epidemiology
Cognitive models
Comorbidity
Cross-Sectional Studies
Disease
Disease models
Education
Female
Gait
Health sciences
Health Status
Humans
Male
Medicine
Medicine & Public Health
Mobility limitation
Modeling
Motor ability
Nervous system diseases
Parkinson disease
Parkinson Disease - diagnosis
Parkinson Disease - epidemiology
Parkinson Disease - psychology
Parkinson's disease
Psychomotor Disorders - epidemiology
Psychomotor Disorders - psychology
Public Health
Quality of Life
Quality of Life Research
Questionnaires
Rating scales
Regression analysis
Severity of Illness Index
Sickness Impact Profile
Social Support
Socioeconomic Factors
Sociology
Statistical methods
Surveys and Questionnaires
Variables
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Summary:Purpose To identify the demographic factors, impairments and activity limitations that contribute to health-related quality of life (HRQOL) in people with idiopathic Parkinson’s disease (PD). Method Two hundred and ten individuals with idiopathic PD who participated in the baseline assessment of a randomized clinical trial were included. The Parkinson’s Disease Questionnaire-39 summary index was used to quantify HRQOL. In order to provide greater clarity regarding the determinants of HRQOL, path analysis was used to explore the relationships between the various predictors in relation to the functioning and disability framework of the International Classification of Functioning model. Results The two models of HRQOL that were examined in this study had a reasonable fit with the data. Activity limitations were found to be the strongest predictor of HRQOL. Limitations in performing self-care activities contributed the most to HRQOL in Model 1 (β = 0.38; p < 0.05), while limitations in functional mobility had the largest contribution in Model 2 (β = –0.31; p < 0.0005). Self-reported history of falls was also found to have a significant and direct relationship with HRQOL in both models (Model 1 β = –0.11; p < 0.05; Model 2 β = –0.21; p < 0.05). Conclusions Health-related quality of life in PD is associated with self-care limitations, mobility limitations, self-reported history of falls and disease duration. Understanding how these factors are inter-related may assist clinicians focus their assessments and develop strategies that aim to minimize the negative functional and social sequelae of this debilitating disease.
ISSN:0962-9343
1573-2649
DOI:10.1007/s11136-012-0289-1