Exposing synonymous mutations

Highlights • Synonymous mutations, which do not result in a change in amino acid sequence, have been considered biologically silent. • Studies in molecular evolution show that synonymous codons are under selective pressure. • Synonymous mutation may affect the function of translated protein through...

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Bibliographic Details
Published in:Trends in genetics 2014-07, Vol.30 (7), p.308-321
Main Authors: Hunt, Ryan C, Simhadri, Vijaya L, Iandoli, Matthew, Sauna, Zuben E, Kimchi-Sarfaty, Chava
Format: Article
Language:English
Subjects:
Animals
Codon
codon usage
Computational Biology - methods
Humans
Medical Education
mRNA structure
Mutation
Nucleic Acid Conformation
Polymorphism, Single Nucleotide
Protein Aggregation, Pathological - genetics
Protein Biosynthesis
Protein Conformation
Protein Stability
Protein Unfolding
RNA Splicing
RNA Stability
RNA, Messenger - chemistry
RNA, Messenger - genetics
RNA, Messenger - metabolism
synonymous mutation
synonymous single nucleotide polymorphism
translation speed
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Summary:Highlights • Synonymous mutations, which do not result in a change in amino acid sequence, have been considered biologically silent. • Studies in molecular evolution show that synonymous codons are under selective pressure. • Synonymous mutation may affect the function of translated protein through diverse cellular mechanisms. • Multiple methods should be applied to investigate synonymous variants and decipher the exact mechanisms by which they impact biological function.
ISSN:0168-9525
DOI:10.1016/j.tig.2014.04.006