Cannabinoids suppress inflammatory and neuropathic pain by targeting alpha 3 glycine receptors

Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models.

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Bibliographic Details
Published in:The Journal of experimental medicine 2012-06, Vol.209 (6), p.1121-1134
Main Authors: Xiong, Wei, Cui, Tanxing, Cheng, Kejun, Yang, Fei, Chen, Shao-Rui, Willenbring, Dan, Guan, Yun, Pan, Hui-Lin, Ren, Ke, Xu, Yan, Zhang, Li
Format: Article
Language:English
Online Access:Get full text
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Description
Summary:Systemic and intrathecal administration of derivatives of a nonpsychoactive component of marijuana significantly suppresses chronic inflammatory and neuropathic pain, without causing analgesic tolerance, in several rodent models.
ISSN:0022-1007
DOI:10.1084/jem.20120242