Postvaccinal, Corticosteroid‐resistant Bullous Pemphigoid in Infancy: Treatment with Intravenous Immunoglobulin

Bullous pemphigoid is an autoimmune subepidermal blistering disorder that typically affects elderly adults but can also occur in childhood. We report on a 3‐month‐old boy who developed bullous pemphigoid 1 week after the second routine administration of a hexavalent vaccine. The disease was resistan...

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Bibliographic Details
Published in:Pediatric dermatology 2014-07, Vol.31 (4), p.e94-e95
Main Authors: Ister, Marielle, Pouessel, Guillaume, Ythier, Hubert, Catteau, Benoit, Carpentier, Olivier
Format: Article
Language:English
Subjects:
Betamethasone - therapeutic use
Diphtheria-Tetanus-Pertussis Vaccine - adverse effects
Drug Resistance
Drug Therapy, Combination
Exanthema
Glucocorticoids - therapeutic use
Hepatitis B Vaccines - adverse effects
Humans
Immunoglobulins, Intravenous - therapeutic use
Infant
Male
Pemphigoid, Bullous - drug therapy
Pemphigoid, Bullous - etiology
Poliovirus Vaccine, Inactivated - adverse effects
Prednisolone - therapeutic use
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Summary:Bullous pemphigoid is an autoimmune subepidermal blistering disorder that typically affects elderly adults but can also occur in childhood. We report on a 3‐month‐old boy who developed bullous pemphigoid 1 week after the second routine administration of a hexavalent vaccine. The disease was resistant to standard therapies (including oral and topical corticosteroids) but was relieved by intravenous immunoglobulin treatment. There was no recurrence of bullous pemphigoid after the next vaccination (3 mos after discontinuation of steroids).
ISSN:0736-8046
1525-1470
DOI:10.1111/pde.12360