Side effects unrelated to disease activity and acceptability of highly effective contraceptive methods in women with systemic lupus erythematosus: a randomized, clinical trial

Abstract Objectives To assess the side effects unrelated to disease activity and the acceptability of combined oral contraceptives (COCs), progestin-only pills (POPs) and copper-releasing intrauterine devices (IUDs) in women with systemic lupus erythematosus (SLE). Study design A randomized clinical...

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Bibliographic Details
Published in:Contraception (Stoneham) 2014-08, Vol.90 (2), p.147-153
Main Authors: Cravioto, María-del-Carmen, Jiménez-Santana, Luisa, Mayorga, Julio, Seuc, Armando H
Format: Article
Language:English
Subjects:
Acne Vulgaris - chemically induced
Adult
Biological and medical sciences
Birth control
Combined oral contraceptives
Contraceptives, Oral, Combined - adverse effects
Contraceptives, Oral, Hormonal - adverse effects
Counseling
Dysmenorrhea - etiology
Female
Follow-Up Studies
Genital system. Reproduction
Gynecology. Andrology. Obstetrics
Hirsutism - chemically induced
Hormonal contraceptives
Humans
Intrauterine device
Intrauterine Devices, Copper - adverse effects
Kaplan-Meier Estimate
Lupus Erythematosus, Systemic - physiopathology
Medical sciences
Nausea - chemically induced
Obstetrics and Gynecology
Patient Acceptance of Health Care
Patient Dropouts
Patient Satisfaction
Pharmacology. Drug treatments
Precision Medicine
Progestin-only pill
Progestins - adverse effects
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Severity of Illness Index
Weight Gain - drug effects
Young Adult
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Summary:Abstract Objectives To assess the side effects unrelated to disease activity and the acceptability of combined oral contraceptives (COCs), progestin-only pills (POPs) and copper-releasing intrauterine devices (IUDs) in women with systemic lupus erythematosus (SLE). Study design A randomized clinical trial including 162 women with SLE, assigned to COC ( n = 54), POP ( n = 54) or IUD ( n = 54). Follow-up visits were conducted after 1, 2, 3, 6, 9 and 12 months of treatment to monitor the presence of symptoms, changes in body weight and blood pressure as well as the development of health problems other than those relating to lupus. Reasons for discontinuation and satisfaction with the use of the assigned method were recorded at the end of treatment. Statistical analysis included descriptive statistics, repeated measure analyses and Kaplan–Meier curves. Results Significantly different discontinuation rates due to any reason [35%, 55%, 29% (p
ISSN:0010-7824
1879-0518
DOI:10.1016/j.contraception.2014.04.001