A specific DNA methylation profile correlates with a high risk of disease progression in stage I classical (Alibert-Bazin type) mycosis fungoides

Summary Background Mycosis fungoides (MF) is the most common type of cutaneous T‐cell lymphoma; in its classical presentation it evolves slowly, but it can have an aggressive course in a subset of patients. Objectives To investigate the impact of epigenetic mechanisms on the progression of early sta...

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Bibliographic Details
Published in:British journal of dermatology (1951) 2014-06, Vol.170 (6), p.1266-1275
Main Authors: Ferrara, G., Pancione, M., Votino, C., Quaglino, P., Tomasini, C., Santucci, M., Pimpinelli, N., Cusano, F., Sabatino, L., Colantuoni, V.
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Biomarkers, Tumor - genetics
Cell Line, Tumor
CpG Islands - genetics
Dermatology
Disease Progression
DNA Methylation - genetics
Epigenesis, Genetic - genetics
Female
General aspects
Genes, Tumor Suppressor
Hematologic and hematopoietic diseases
Humans
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Male
Medical sciences
Middle Aged
Mycosis Fungoides - genetics
Risk Factors
Skin Neoplasms - genetics
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Summary:Summary Background Mycosis fungoides (MF) is the most common type of cutaneous T‐cell lymphoma; in its classical presentation it evolves slowly, but it can have an aggressive course in a subset of patients. Objectives To investigate the impact of epigenetic mechanisms on the progression of early stage MF. Methods We analysed DNA methylation at 12 different loci and long interspersed nucleotide elements‐1 (LINE‐1), as a surrogate marker of global methylation, on tissue samples from 41 patients with stage I MF followed up for at least 12 years or until disease progression. The methylation profiles were also analysed in two T‐cell lymphoma cell lines and correlated with gene expression. Results The selected loci were methylated in a tumour‐specific manner; concomitant hypermethylation of at least four loci was more frequent in cases progressing within 1–3 and 3–6 years than in late‐progressive or non‐progressive cases. LINE‐1 methylation was significantly lower in rapidly progressive MF at 3 years (61%, P 
ISSN:0007-0963
1365-2133
DOI:10.1111/bjd.12717