Novel serotypes 105 and 116 are members of distinct subgroups of human enterovirus C

The full coding sequences of two novel human enterovirus (HEV)-C serotypes 105 and 116, sampled in the Republic of the Congo in 2010 and in Russia in 2011, were identified in this study. Enterovirus (EV)-105 was closest to EV-104 in the 5' NTR and to EV-109 in the coding genome region. It had t...

Full description

Saved in:
Bibliographic Details
Published in:Journal of general virology 2012-11, Vol.93 (Pt 11), p.2357-2362
Main Authors: Lukashev, Alexander N, Drexler, Jan Felix, Kotova, Valeria O, Amjaga, Elena N, Reznik, Vadim I, Gmyl, Anatoly P, Grard, Gilda, Taty Taty, Raphael, Trotsenko, Olga E, Leroy, Eric M, Drosten, Christian
Format: Article
Language:English
Subjects:
Congo - epidemiology
Coxsackievirus
Enterovirus
Enterovirus C, Human - classification
Enterovirus C, Human - genetics
Enterovirus Infections - epidemiology
Enterovirus Infections - virology
Genetic Variation
Humans
Phylogeny
Reassortant Viruses
RNA, Viral - genetics
Russia - epidemiology
Serotyping
Virus Replication
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The full coding sequences of two novel human enterovirus (HEV)-C serotypes 105 and 116, sampled in the Republic of the Congo in 2010 and in Russia in 2011, were identified in this study. Enterovirus (EV)-105 was closest to EV-104 in the 5' NTR and to EV-109 in the coding genome region. It had the same unconventional 5' NTR as EV-104 and EV-109. The non-cytopathogenic EV-116 was phylogenetically close to coxsackievirus (CV)-A1, CV-A19 and CV-A22, which also cannot be propagated in routinely used cell cultures. There were signs of recombination within this subgroup of HEV-C; however, recombination with conventional HEV-C was restricted, implying partial reproductive isolation. As there is also evidence of different permissive replication systems and distinct genetic properties of these subgroups, they may represent subspecies of the HEV-C species or different stages of speciation.
ISSN:0022-1317
1465-2099
1465-2099
DOI:10.1099/vir.0.043216-0