effect of antioxidant vitamins E and C on cognitive performance of the elderly with mild cognitive impairment in Isfahan, Iran: a double-blind, randomized, placebo-controlled trial

PURPOSE: This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran. METHODS: About 256 elderly with mild cognitive impairment, aged 60–75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year. B...

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Bibliographic Details
Published in:European journal of nutrition 2014-08, Vol.53 (5), p.1255-1262
Main Authors: Alavi Naeini, A. M, Elmadfa, I, Djazayery, A, Barekatain, M, Aghaye Ghazvini, M. R, Djalali, M, Feizi, A
Format: Article
Language:English
Subjects:
Aged
antioxidant activity
antioxidants
Antioxidants - administration & dosage
ascorbic acid
Ascorbic Acid - administration & dosage
Biological and medical sciences
biomarkers
blood serum
central nervous system diseases
Chemistry
Chemistry and Materials Science
cognition
Cognition - drug effects
Cognitive Dysfunction - drug therapy
Deoxyguanosine - analogs & derivatives
Deoxyguanosine - blood
Dietary Supplements
Double-Blind Method
elderly
Feeding. Feeding behavior
Female
Fundamental and applied biological sciences. Psychology
Geriatrics
glutathione
Glutathione - blood
Humans
Iran
Male
malondialdehyde
Malondialdehyde - blood
Medical sciences
Middle Aged
Nutrition
Original Contribution
oxidative stress
Oxidative Stress - drug effects
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
sociodemographic characteristics
Vertebrates: anatomy and physiology, studies on body, several organs or systems
vitamin E
Vitamin E - administration & dosage
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Summary:PURPOSE: This study was carried out to investigate the effect of vitamins E and C on cognitive performance among the elderly in Iran. METHODS: About 256 elderly with mild cognitive impairment, aged 60–75 years, received 300 mg of vitamin E plus 400 mg of vitamin C or placebo daily just for 1 year. BACKGROUND: Demographic characteristics, anthropometric variables food consumption, cognitive function by Mini-Mental State Examination (MMSE), and some of the oxidative stress biomarkers were examined. RESULTS: Antioxidant supplementation reduced malondialdehyde level (P < 0.001) and raised total antioxidant capacity (P < 0.001) and glutathione (P < 0.01). The serum 8-hydroxydeoxyguanosine remained unchanged (P < 0.4). After adjusting for the covariates effects, MMSE scores following 6- (25.88 ± 0.17) and 12-month antioxidant supplementation (26.8 ± 0.17) did not differ from control group (25.86 ± 0.18 and 26.59 ± 0.18, respectively). CONCLUSION: Despite significant improvement in most of the oxidative stress biomarkers, antioxidants’ supplementation was not observed to enhance cognitive performance. A large number of kinetic and/or dynamic factors could be suspected.
ISSN:1436-6207
1436-6215
DOI:10.1007/s00394-013-0628-1