Template-induced polymorphic selectivity: the effects of surface chemistry and solute concentration on carbamazepine crystallisation

Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitant...

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Bibliographic Details
Published in:CrystEngComm 2014-01, Vol.16 (23), p.4927-4930
Main Authors: Parambil, Jose V., Poornachary, Sendhil K., Tan, Reginald B. H., Heng, Jerry Y. Y.
Format: Article
Language:English
Subjects:
Cooling
Crystallization
Crystals
Nucleation
Silanes
Supersaturation
Surface chemistry
Vials
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Summary:Cooling crystallisation of carbamazepine solution in glass vials functionalised with different silane molecules resulted in preferential nucleation of metastable form II or stable form III polymorphs within a definite range of supersaturation. In contrast, the two crystal forms nucleated concomitantly on a control substrate under similar solution conditions.
ISSN:1466-8033
1466-8033
DOI:10.1039/C3CE42622J