The formation of linear aggregates in magnetic hyperthermia: Implications on specific absorption rate and magnetic anisotropy

[Display omitted] •Colloidally stable particles formed linear aggregates in an alternating magnetic field.•Chains of magnetic particles may effect the application of these materials.•The size of the chains was dependent upon the stabilizing polymer molecular weight.•Calculations demonstrated that sp...

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Bibliographic Details
Published in:Journal of colloid and interface science 2014-06, Vol.424 (424), p.141-151
Main Authors: Saville, Steven L., Qi, Bin, Baker, Jonathon, Stone, Roland, Camley, Robert E., Livesey, Karen L., Ye, Longfei, Crawford, Thomas M., Thompson Mefford, O.
Format: Article
Language:English
Subjects:
Aggregates
Anisotropy
Brushes
Chaining
Chains (polymeric)
Chemistry
Colloidal arrangement
Colloidal state and disperse state
Colloids
Colloids - chemistry
Design engineering
Equipment Design
Exact sciences and technology
General and physical chemistry
Hyperthermia
Hyperthermia, Induced - instrumentation
Magnetic
Magnetic Fields
Magnetite
Magnetite Nanoparticles - chemistry
Magnetite Nanoparticles - ultrastructure
Nanoparticle
Nanoparticles
Particle Size
Physical and chemical studies. Granulometry. Electrokinetic phenomena
Polymer
Polymers - chemistry
Self assembly
Synthetic aperture radar
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Summary:[Display omitted] •Colloidally stable particles formed linear aggregates in an alternating magnetic field.•Chains of magnetic particles may effect the application of these materials.•The size of the chains was dependent upon the stabilizing polymer molecular weight.•Calculations demonstrated that spacing effects the magnetic material properties. The design and application of magnetic nanoparticles for use as magnetic hyperthermia agents has garnered increasing interest over the past several years. When designing these systems, the fundamentals of particle design play a key role in the observed specific absorption rate (SAR). This includes the particle's core size, polymer brush length, and colloidal arrangement. While the role of particle core size on the observed SAR has been significantly reported, the role of the polymer brush length has not attracted as much attention. It has recently been reported that for some suspensions linear aggregates form in the presence of an applied external magnetic field, i.e. chains of magnetic particles. The formation of these chains may have the potential for a dramatic impact on the biomedical application of these materials, specifically the efficiency of the particles to transfer magnetic energy to the surrounding cells. In this study we demonstrate the dependence of SAR on magnetite nanoparticle core size and brush length as well as observe the formation of magnetically induced colloidal arrangements. Colloidally stable magnetic nanoparticles were demonstrated to form linear aggregates in an alternating magnetic field. The length and distribution of the aggregates were dependent upon the stabilizing polymer molecular weight. As the molecular weight of the stabilizing layer increased, the magnetic interparticle interactions decreased therefore limiting chain formation. In addition, theoretical calculations demonstrated that interparticle spacing has a significant impact on the magnetic behavior of these materials. This work has several implications for the design of nanoparticle and magnetic hyperthermia systems, while improving understanding of how colloidal arrangement affects SAR.
ISSN:0021-9797
1095-7103
DOI:10.1016/j.jcis.2014.03.007