Effects of Antenatal Hypoxia on the Parameters of Tissue Homeostasis in the Liver of Albino Rats

We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that an...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2014-07, Vol.157 (3), p.327-329
Main Authors: Pinaeva, O. G., Lebed’ko, O. A., Yakovenko, D. V., Timoshin, S. S., Pinaev, S. K., Sazonova, E. N.
Format: Article
Language:English
Subjects:
Animals
Animals, Outbred Strains
Biomedical and Life Sciences
Biomedicine
Body Weight
Cell Biology
Cell Hypoxia
DNA
Female
Hepatocytes - physiology
Homeostasis
Internal Medicine
Laboratory Medicine
Liver - pathology
Organ Size
Pathology
Pregnancy
Prenatal Exposure Delayed Effects - pathology
Rats
S Phase Cell Cycle Checkpoints
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Summary:We studied age-dependent dynamics of some liver parameters in albino rats after antenatal hypoxia. A decrease in body weight, absolute liver weight in newborn and mature rats, and a reduction of relative weight of the liver in mature animals were observed under these conditions. It was found that antenatal hypoxia promotes a decrease in DNA-synthetic activity of hepatocytes, intensifies free radical processes in the liver of newborn rats, and reduces the number of nucleoli in hepatocytes. In mature animals, antenatal hypoxia was followed by a decrease in hepatocyte sizes and area of nucleoli, an increase in the number of binuclear cells relative to mononuclear cells, and a decrease in the number of nucleoli in hepatocyte nuclei. These data can reflect impairment of tissue homeostasis in the liver of mammals exposed to antenatal hypoxia.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-014-2557-2