Long-term outcomes associated with hospital acquired thrombocytopenia among patients with non–ST-segment elevation acute coronary syndrome

Background Acquired thrombocytopenia after a non–ST-segment-elevation-acute coronary syndrome (NSTE-ACS) has been associated with increased in-hospital mortality and hemorrhagic complications, but longer term outcomes are unclear. We examined the association between thrombocytopenia and long-term ou...

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Bibliographic Details
Published in:The American heart journal 2014-08, Vol.168 (2), p.189-196.e1
Main Authors: Vora, Amit N., MD, MPH, Chenier, Michael, MD, MPH, Schulte, Phillip J., PhD, Goodman, Shaun, MD, MSc, Peterson, Eric D., MD, MPH, Pieper, Karen, MS, Jolicoeur, Marc E., MD, MHS, Mahaffey, Kenneth W., MD, White, Harvey, MB, CHB, DSc, Wang, Tracy Y., MD, MHS, MSc
Format: Article
Language:English
Subjects:
Acute Coronary Syndrome - mortality
Acute coronary syndromes
Aged
Cardiovascular
Drug therapy
Female
Heart attacks
Hospital Mortality
Hospitalization
Humans
Kaplan-Meier Estimate
Male
Middle Aged
Mortality
Platelet Aggregation Inhibitors - therapeutic use
Platelet Count
Severity of Illness Index
Thrombocytopenia - mortality
Treatment Outcome
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Summary:Background Acquired thrombocytopenia after a non–ST-segment-elevation-acute coronary syndrome (NSTE-ACS) has been associated with increased in-hospital mortality and hemorrhagic complications, but longer term outcomes are unclear. We examined the association between thrombocytopenia and long-term outcomes after accounting for thrombocytopenia severity and discharge medication use. Methods Data from 7,435 NSTE-ACS patients enrolled in the SYNERGY trial were analyzed. Severe thrombocytopenia was defined as a nadir platelet count
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2014.04.010