A clinical appraisal of different Z-score equations for aortic root assessment in the diagnostic evaluation of Marfan syndrome

Aortic sinus diameter dilatation expressed as a Z-score >2.0 is diagnostic in Marfan syndrome. In addition to the classic equation (Z1) for calculating Z-scores, two new equations were recently introduced (Z2 and Z3). We studied the effects of obesity, age, and the absolute cut point of 40 mm on...

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Bibliographic Details
Published in:	Genetics in medicine 2013-07, Vol.15 (7), p.528-532
Main Authors:	van Kimmenade, Roland R J, Kempers, Marlies, de Boer, Menko-Jan, Loeys, Bart L, Timmermans, Janneke
Format:	Article
Language:	eng
Subjects:	Adult Age Factors Aorta - diagnostic imaging Aorta - pathology Body Height Body Mass Index Dilatation, Pathologic - diagnostic imaging Echocardiography Female Humans Male Marfan Syndrome - pathology Marfan Syndrome - physiopathology Marfan Syndrome - surgery Models, Cardiovascular Obesity - physiopathology Sinus of Valsalva - physiopathology Young Adult
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Summary:	Aortic sinus diameter dilatation expressed as a Z-score >2.0 is diagnostic in Marfan syndrome. In addition to the classic equation (Z1) for calculating Z-scores, two new equations were recently introduced (Z2 and Z3). We studied the effects of obesity, age, and the absolute cut point of 40 mm on these three equations in 2,674 echocardiographic measurements of 260 patients with Marfan syndrome. Diameters ≥40 mm were associated with Z1 scores
ISSN:	1098-3600 1530-0366