Live birth using vitrified–warmed oocytes in invasive ovarian cancer: case report and literature review

Abstract This article reports the live birth of a healthy newborn using vitrified–warmed oocytes in a young patient with invasive mucinous ovarian carcinoma (stage Ic). Diagnosis was performed after a laparoscopic left adnexectomy. She underwent two cycles of ovarian stimulation, and 14 oocytes were...

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Published in:Reproductive biomedicine online 2014-06, Vol.28 (6), p.663-668
Main Authors: Alvarez, Manuel, Solé, Miquel, Devesa, Marta, Fábregas, Rafael, Boada, Montserrat, Tur, Rosa, Coroleu, Buenaventura, Veiga, Anna, Barri, Pedro N
Format: Article
Language:English
Subjects:
Adult
Embryo Transfer
Female
fertility preservation
Fertility Preservation - ethics
Fertility Preservation - methods
fertility-sparing surgery
Fertilization in Vitro - methods
heterotopic pregnancy
Humans
Infant, Newborn
ivf in cancer patients
Live Birth
Obstetrics and Gynecology
oocyte vitrification
Oocytes
ovarian cancer
Ovarian Neoplasms - surgery
Ovulation Induction
Pregnancy
Treatment Outcome
Vitrification
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Summary:Abstract This article reports the live birth of a healthy newborn using vitrified–warmed oocytes in a young patient with invasive mucinous ovarian carcinoma (stage Ic). Diagnosis was performed after a laparoscopic left adnexectomy. She underwent two cycles of ovarian stimulation, and 14 oocytes were vitrified before fertility-sparing surgery with uterus preservation went ahead. One year later, a transfer of two embryos was performed after insemination of warmed oocytes. Eighteen days after the transfer, she underwent a laparotomy because of abdominal pain, vaginal bleeding and haemoperitoneum. A right cornual ectopic pregnancy in the uterus was diagnosed and a wedge resection was performed to resolve it. One week later, a viable intrauterine pregnancy was confirmed under ultrasound. An elective Caesarean section was performed at week 38 of gestation, resulting in the birth of a healthy boy weighing 2650 g. As far as is known, this is the first live birth reported through vitrified–warmed oocytes in a patient with invasive ovarian cancer. Although oocyte vitrification is an alternative to be considered for fertility preservation in highly selected cases of ovarian cancer, controversial issues are discussed. Fertility preservation is a proven possibility in some cancer patients according to their age, disease and time available until the beginning of their oncological treatment. Although oocyte vitrification is an alternative to be considered for fertility preservation in highly selected cases of ovarian cancer, no live birth has been reported. We report the live birth of a healthy newborn through vitrified–warmed oocytes in a young patient with invasive mucinous ovarian carcinoma (stage Ic). Diagnosis was performed after a laparoscopic left adnexectomy. She underwent two cycles of ovarian stimulation, and 14 oocytes were vitrified before fertility-sparing surgery with uterus preservation went ahead. One year later, a transfer of two embryos was performed after the insemination of the warmed oocytes. Eighteen days after the transfer she underwent a laparotomy because of abdominal pain, vaginal bleeding and haemoperitoneum. A right cornual ectopic pregnancy in the uterus was diagnosed and a wedge resection was performed to resolve it. One week later, a viable intrauterine pregnancy was confirmed under ultrasound. An elective Caesarean section was performed at week 38 of gestation, resulting in the birth of a healthy boy weighing 2650 g. To our knowledge, this
ISSN:1472-6483
1472-6491
DOI:10.1016/j.rbmo.2014.02.010