Natural and synthetic poly(malic acid)-based derivates: a family of versatile biopolymers for the design of drug nanocarriers

Abstract The field of specific drug delivery is an expanding research domain. Besides the use of liposomes formed from various lipids, natural and synthetic polymers have been developed to prepare more efficient drug delivery systems either under macromolecular prodrugs or under particulate nanovect...

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Bibliographic Details
Published in:Journal of drug targeting 2014-08, Vol.22 (7), p.556-575
Main Authors: Loyer, Pascal, Cammas-Marion, Sandrine
Format: Article
Language:English
Subjects:
Animals
Biopolymers - chemistry
Cancer
Cell Line, Tumor
Chemical Sciences
Degradable polymers
Drug Carriers - chemistry
drug delivery systems
Drug Design
drug-polymer conjugates
Humans
Life Sciences
Malates - chemical synthesis
Malates - chemistry
Malates - pharmacokinetics
Molecular Structure
nanoparticles
Nanoparticles - chemistry
Pharmaceutical Preparations - administration & dosage
poly(malic acid)
Polymers
Polymers - chemical synthesis
Polymers - chemistry
Polymers - pharmacokinetics
targeting
Tissue Distribution
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Summary:Abstract The field of specific drug delivery is an expanding research domain. Besides the use of liposomes formed from various lipids, natural and synthetic polymers have been developed to prepare more efficient drug delivery systems either under macromolecular prodrugs or under particulate nanovectors. To ameliorate the biocompatibility of such nanocarriers, degradable natural or synthetic polymers have attracted the interest of many researchers. In this context, poly(malic acid) (PMLA) extracted from microorganisms or synthesized from malic or aspartic acid was used to prepare water-soluble drug carriers or nanoparticles. Within this review, both the preparation and the applications of PMLA derivatives are described emphasizing the in vitro and in vivo assays. The results obtained by several groups highlight the interest of such polyesters in the field of drug delivery.
ISSN:1061-186X
1029-2330
DOI:10.3109/1061186X.2014.936871