Carcinoid heart disease: Current understanding and future directions

Carcinoid tumors are rare and aggressive malignancies. A multitude of vasoactive agents are central to the systemic effects of these tumors. The additional burden of cardiac dysfunction heralds a steep decline in quality of life and survival. Unfortunately, by the time carcinoid syndrome surfaces cl...

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Bibliographic Details
Published in:The American heart journal 2014-06, Vol.167 (6), p.789-795
Main Authors: Patel, Chirdeep, MD, Mathur, Moses, MD, MSc, Escarcega, Ricardo O., MD, Bove, Alfred A., MD, PhD
Format: Article
Language:English
Subjects:
Antineoplastic Agents, Hormonal - therapeutic use
Balloon Valvuloplasty
Carcinoid Heart Disease - diagnosis
Carcinoid Heart Disease - etiology
Carcinoid Heart Disease - therapy
Carcinoid Tumor - complications
Carcinoid Tumor - surgery
Cardiovascular
Cardiovascular disease
Cell division
Echocardiography
Heart failure
Heart surgery
Heart Valve Prosthesis Implantation
Humans
Kinases
Medical prognosis
Mortality
Octreotide - therapeutic use
Prognosis
Pulmonary arteries
Rodents
Serotonin
Treatment Outcome
Tumors
Vascular endothelial growth factor
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Summary:Carcinoid tumors are rare and aggressive malignancies. A multitude of vasoactive agents are central to the systemic effects of these tumors. The additional burden of cardiac dysfunction heralds a steep decline in quality of life and survival. Unfortunately, by the time carcinoid syndrome surfaces clinically, the likelihood of cardiac involvement is 50%. Although medical therapies such as somatostatin analogues may provide some symptom relief, they offer no mortality benefit. On the other hand, referral to surgery following early detection has shown increased survival. The prompt recognition of this disease is therefore of the utmost importance.
ISSN:0002-8703
1097-6744
DOI:10.1016/j.ahj.2014.03.018