Increased plasma levels of BDNF and inflammatory markers in Alzheimer's disease

Abstract Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Neurotrophic factors and inflammatory markers may play considerable roles in AD. In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma levels of brain derived neurotrophic factor (B...

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Bibliographic Details
Published in:Journal of psychiatric research 2014-06, Vol.53, p.166-172
Main Authors: Faria, Mayara Chaves, Gonçalves, Gisele Santos, Rocha, Natália Pessoa, Moraes, Edgar Nunes, Bicalho, Maria Aparecida, Gualberto Cintra, Marco Túlio, Jardim de Paula, Jonas, José Ravic de Miranda, Luís Felipe, Clayton de Souza Ferreira, Alessandro, Teixeira, Antônio Lúcio, Gomes, Karina Braga, Carvalho, Maria das Graças, Sousa, Lirlândia P
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Aged
Aged, 80 and over
Alzheimer Disease - blood
Alzheimer's disease
Biological and medical sciences
Biomarkers
Brain
Brain derived neurotrophic factor
Brain-Derived Neurotrophic Factor - blood
Cognitive Dysfunction - blood
Cognitive impairment
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Elderly people
Enzyme-Linked Immunosorbent Assay
Female
Humans
Inflammation
Intercellular Adhesion Molecule-1 - blood
Male
Medical sciences
Nerve Growth Factor - blood
Nervous system
Neurodegeneration
Neurology
Neurotrophic factors
Neurotrophins
Organic mental disorders. Neuropsychology
Plasma levels
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Receptors, Tumor Necrosis Factor, Type I - blood
Receptors, Tumor Necrosis Factor, Type II - blood
Statistics, Nonparametric
sTNFR1
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Summary:Abstract Alzheimer's disease (AD) is the most common cause of dementia in the elderly. Neurotrophic factors and inflammatory markers may play considerable roles in AD. In this study we measured, through Enzyme-Linked Immunosorbent Assay, the plasma levels of brain derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and neuronal growth factor (NGF), as well as tumor necrosis factor-alpha soluble receptors, sTNFR1 and sTNFR2, and soluble intercellular adhesion molecule 1 (sICAM-1), in 50 AD patients, 37 patients with mild cognitive impairment (MCI) and 56 healthy elderly controls. BDNF levels, expressed as median and interquartile range, were higher for AD patients (2545.3, 1497.4–4153.4 pg/ml) compared to controls (1503.8, 802.3–2378.4 pg/ml), P  
ISSN:0022-3956
1879-1379
DOI:10.1016/j.jpsychires.2014.01.019