Subgenual anterior cingulate cortex activity covariation with cardiac vagal control is altered in depression

Abstract Background We tested the hypothesis that subgenual anterior cingulate cortex (sgACC) participates in concurrently regulating shifts in both affective state and cardiac vagal control. Methods Eleven healthy adults and 8 depressed subjects performed the Emotional Counting Stroop task in alter...

Full description

Saved in:
Bibliographic Details
Published in:Journal of affective disorders 2013-09, Vol.150 (2), p.565-570
Main Authors: Lane, Richard D, Weidenbacher, Hollis, Smith, Ryan, Fort, Carolyn, Thayer, Julian F, Allen, John J.B
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Affect
Affective disorders
Biological and medical sciences
Case-Control Studies
Cortex
Depression
Depression - physiopathology
Dysfunction
Electrocardiography
Emotion
Emotions - physiology
Female
Fmri
Gyrus Cinguli - physiopathology
Heart - innervation
Heart - physiopathology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Mood disorders
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Signals
Subgenual anterior cingulate cortex
Vagal tone
Vagus Nerve - physiopathology
Volunteers
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Background We tested the hypothesis that subgenual anterior cingulate cortex (sgACC) participates in concurrently regulating shifts in both affective state and cardiac vagal control. Methods Eleven healthy adults and 8 depressed subjects performed the Emotional Counting Stroop task in alternating 15-second blocks of emotion words and neutral words while undergoing functional magnetic resonance imaging (fMRI) and electrocardiography (ECG). We measured the absolute value of change between adjacent 15-second blocks in both cardiac vagal control and the BOLD signal in specific regions of interest. Results Strong positive correlations were observed in healthy control participants between changes in cardiac vagal control and changes in BOLD signal intensity in sgACC (BA25) (right: r =.67, p
ISSN:0165-0327
1573-2517
DOI:10.1016/j.jad.2013.02.005