A molecular rotor for measuring viscosity in plasma membranes of live cells

Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor su...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (40), p.5282-5284
Main Authors: López-Duarte, Ismael, Vu, Thanh Truc, Izquierdo, M Angeles, Bull, James A, Kuimova, Marina K
Format: Article
Language:English
Subjects:
Boron Compounds - chemistry
Cell Membrane - chemistry
Female
Fluorescent Dyes - chemistry
Humans
Imaging
Mapping
Membranes
Microscopy, Confocal
Ovarian Neoplasms - pathology
Rotors
Spectrometry, Fluorescence
Spectroscopy
Synthesis
Tumor Cells, Cultured
Viscosity
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Summary:Molecular rotors have emerged as versatile probes for microscopic viscosity in live cells, however, the exclusive localisation of rotors in the plasma membrane has remained elusive. We report the synthesis, spectroscopic characterisation and live cell imaging of a new BODIPY-based molecular rotor suitable for mapping viscosity in the cell plasma membrane.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc47530a