Haemoglobin levels and health-related quality of life in young and elderly patients on specialized predialysis care

In predialysis patients, the optimal treatment choices for controlling haemoglobin (Hb) are unknown, because targeting high Hb levels has negative effects--poorer survival--but possible positive effects as well--better health-related quality of life (HRQOL). Moreover, these effects may be different...

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Published in:Nephrology, dialysis, transplantation dialysis, transplantation, 2014-07, Vol.29 (7), p.1391-1398
Main Authors: de Goeij, Moniek C M, Meuleman, Yvette, van Dijk, Sandra, Grootendorst, Diana C, Dekker, Friedo W, Halbesma, Nynke
Format: Article
Language:English
Subjects:
Age Factors
Aged
Anemia - metabolism
Anemia - prevention & control
Biomarkers - blood
Erythropoietin - metabolism
Female
Follow-Up Studies
Glomerular Filtration Rate
Hemoglobins - metabolism
Humans
Kidney Diseases - blood
Kidney Diseases - psychology
Kidney Diseases - therapy
Male
Middle Aged
Prognosis
Prospective Studies
Quality of Life - psychology
Renal Dialysis
Surveys and Questionnaires
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Summary:In predialysis patients, the optimal treatment choices for controlling haemoglobin (Hb) are unknown, because targeting high Hb levels has negative effects--poorer survival--but possible positive effects as well--better health-related quality of life (HRQOL). Moreover, these effects may be different in specific subgroups (e.g. young versus elderly). In the PREPARE-2 follow-up study, incident predialysis patients were included (2004-2011) when referred to 1 of the 25 participating Dutch outpatient clinics. HRQOL was assessed at 6-month intervals with the short form-36 (SF-36) questionnaire [physical/mental summary measure and eight subscales (range 0-100)]. A linear mixed model was used to associate Hb [
ISSN:0931-0509
1460-2385
DOI:10.1093/ndt/gft533