Heterochromatin protein 1 expression is reduced in human thyroid malignancy

Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thy...

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Bibliographic Details
Published in:Laboratory investigation 2014-07, Vol.94 (7), p.788-795
Main Authors: Tretiakova, Maria S, Bond, Sarah D, Wheeler, David, Contreras, Alejandro, Kocherginsky, Masha, Kroll, Todd G, Hale, Tracy K
Format: Article
Language:English
Subjects:
3' Untranslated Regions - genetics
Biomarkers, Tumor - metabolism
Cell Line
Chromobox Protein Homolog 5
Chromosomal Proteins, Non-Histone - biosynthesis
Chromosomal Proteins, Non-Histone - genetics
Down-Regulation
Gene Expression Regulation, Neoplastic
Humans
Immunoblotting
Immunohistochemistry
Luciferases - genetics
Luciferases - metabolism
MicroRNAs - genetics
Neoplasm Metastasis
Thyroid Gland - metabolism
Thyroid Gland - pathology
Thyroid Neoplasms - genetics
Thyroid Neoplasms - metabolism
Thyroid Neoplasms - pathology
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Summary:Owing to the loss of heterochromatin integrity that occurs during thyroid tumorigenesis, the expression of Heterochromatin Protein 1 isoforms HP1α and HP1β was assessed by immunohistochemistry in 189 thyroid tumors and non-neoplastic tissues. Expression of HP1β was significantly decreased in all thyroid lesions, except in follicular adenomas, when compared with matched adjacent normal tissue. This loss of HP1β expression may in part be caused by microRNA dysregulation. An example is miR-205, a microRNA that is abundantly upregulated in thyroid carcinomas and shown to reduce the expression of HP1β. In contrast to HP1β, HP1α expression was only reduced in metastatic carcinomas and poorly differentiated lesions. These results suggest the reduction of HP1β followed by a decrease in HP1α contributes to the pathogenesis of thyroid carcinomas, and their loss is a potential marker of thyroid malignancy and metastatic potential, respectively.
ISSN:0023-6837
1530-0307
DOI:10.1038/labinvest.2014.68