Back to the heart: The protective role of adiponectin

Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively s...

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Bibliographic Details
Published in:Pharmacological research 2014-04, Vol.82, p.9-20
Main Authors: Caselli, C., D’Amico, A., Cabiati, M., Prescimone, T., Del Ry, S., Giannessi, D.
Format: Article
Language:English
Subjects:
Adiponectin
Adiponectin - genetics
Adiponectin - metabolism
Adiponectin system
Animals
Cardiovascular Diseases - drug therapy
Cardiovascular Diseases - metabolism
Cardiovascular protection
Humans
Inflammation - metabolism
Myocardium - metabolism
Obesity - metabolism
Therapeutic target
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Summary:Cardiovascular disease (CVD) is the leading cause of death worldwide and the prevalence of obesity and diabetes are increasing. In obesity, adipose tissue increases the secretion of bioactive mediators (adipokines) that may represent a key mechanism linking obesity to CVD. Adiponectin, extensively studied in metabolic diseases, exerts anti-diabetic, anti-atherogenic and anti-inflammatory activities. Due to these positive actions, the role of adiponectin in cardiovascular protection has been evaluated in recent years. In particular, for its potential therapeutic benefits in humans, adiponectin has become the subject of intense preclinical research. In the cardiovascular context, understanding of the cellular and molecular mechanisms underlying the adiponectin system, throughout its secretion, regulation and signaling, is critical for designing new drugs that target adiponectin system molecules. This review focused on recent advances regarding molecular mechanisms related to protective effects of the adiponectin system on both cardiac and vascular compartments and its potential use as a target for therapeutic intervention of CVD.
ISSN:1043-6618
1096-1186
DOI:10.1016/j.phrs.2014.03.003