The relationship between glycemic control and BNP levels in diabetic patients

Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved. The study was performed in a prospective design. The study p...

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Bibliographic Details
Published in:Cardiology journal 2014-01, Vol.21 (3), p.252-256
Main Authors: Dal, Kursat, Ata, Naim, Yavuz, Bunyamin, Sen, Omer, Deveci, Onur Sinan, Aksoz, Zekeriya, Yildirim, Aslihan Mete, Uygungelen, Bulent, Akin, Kadir Okhan, Beyan, Esin, Ertugrul, Derun Taner
Format: Article
Language:English
Subjects:
Blood Glucose - metabolism
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Fasting
Female
Follow-Up Studies
Glucose
Glycated Hemoglobin A - metabolism
Heart Failure - blood
Heart Failure - complications
Humans
Male
Middle Aged
Natriuretic Peptide, Brain - blood
Prospective Studies
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Summary:Glycemic control affects cardiovascular risk factors positively. The purpose of this study was to assess B-type natriuretic peptide (BNP) levels in patients with poorly controlled diabetes before and after glycemic regulation was achieved. The study was performed in a prospective design. The study population consisted of 79 consecutive diabetic patients with poor glycemic control. All subjects underwent transthoracic echocardiography. Levels of fasting plasma glucose, glycosylated hemoglobin (HbA1c), lipid parameters, and BNP were measured before the onset of the treatment and after glycemic regulation was achieved. A significant decrease in BNP (95.0 [4.0-1807] ng/L vs. 52.0 [2.1-987.0] ng/L, p < 0.001) levels were observed, after improving glycemic control. The decrease in BNP levels was positively correlated with the decrease in HbA1c (r = 0.345, p = 0.003) and fasting plasma glucose (r = 0.366, p = 0.002). There was no correlation between the decrease in BNP levels and lipid parameters (p = NS). We conclude that poor glycemic control may cause high levels of BNP which may lead to overdiagnosis of congestive heart failure. We suggest that HbA1c and fasting plasma glucose should be checked in patients with high levels of BNP.
ISSN:1897-5593
1897-5593
1898-018X
DOI:10.5603/cj.a2013.0109