Sarcoma classification: An update based on the 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone

The 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone incorporates changes in tumor classification, as well as new genetic insights into the pathogenesis of many different tumor types that have emerged over the 11 years since the publication of the prior volume. This ar...

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Bibliographic Details
Published in:Cancer 2014-06, Vol.120 (12), p.1763-1774
Main Author: Doyle, Leona A.
Format: Article
Language:English
Subjects:
Biological and medical sciences
bone
Bone Neoplasms - classification
Bone Neoplasms - pathology
Diseases of the osteoarticular system
Humans
Medical sciences
Multiple tumors. Solid tumors. Tumors in childhood (general aspects)
sarcoma
Sarcoma - classification
Sarcoma - pathology
soft tissue
Soft Tissue Neoplasms - classification
Soft Tissue Neoplasms - pathology
tumor
tumor classification
Tumors
Tumors of striated muscle and skeleton
World Health Organization
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Summary:The 2013 World Health Organization Classification of Tumors of Soft Tissue and Bone incorporates changes in tumor classification, as well as new genetic insights into the pathogenesis of many different tumor types that have emerged over the 11 years since the publication of the prior volume. This article reviews changes in the classification of soft tissue and bone sarcomas as well as tumors of intermediate biologic potential in the 2013 World Health Organization volume, new molecular insights into these tumors, and associated surgical and clinical implications. Cancer 2014;120:1763–1774. © 2014 American Cancer Society. Since the publication of the prior World Health Organization (WHO) Classification of Tumors of Soft Tissue and Bone 11 years ago, new clinicopathologic and genetic features of many soft tissue and bone tumors have been characterized, allowing obsolete diagnostic categories to be removed and new tumor types to be added. This article reviews the changes in the 2013 WHO classification, along with new genetic data that have emerged even since the publication of the current volume.
ISSN:0008-543X
1097-0142
DOI:10.1002/cncr.28657