Effects of fipronil on dogs over Triatoma infestans, the main vector of Trypanosoma cruzi, causative agent of Chagas disease

Chagas disease is the most important endemic disease in Latin America, mainly transmitted by Triatoma infestans in the Southern Cone countries of South America. Dogs are one of the main domestic reservoirs of Trypanosoma cruzi, the etiological agent of Chagas disease. The presence of dogs in rural h...

Full description

Saved in:
Bibliographic Details
Published in:Parasitology research (1987) 2012-10, Vol.111 (4), p.1457-1462
Main Authors: Amelotti, Ivana, Catalá, Silvia S., Gorla, David E.
Format: Article
Language:English
Subjects:
Animals
Antiparasitic Agents - administration & dosage
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Chagas' disease
Dog Diseases - prevention & control
Dogs
Ectoparasitic Infestations - prevention & control
Ectoparasitic Infestations - veterinary
Feeding Behavior - drug effects
Fundamental and applied biological sciences. Psychology
General aspects
General aspects and techniques. Study of several systematic groups. Models
Health aspects
Human protozoal diseases
Immunology
Infectious diseases
Insecticides
Invertebrates
Medical Microbiology
Medical sciences
Microbiology
Nymph - drug effects
Original Paper
Parasitic diseases
Protozoal diseases
Pyrazoles - administration & dosage
Survival Analysis
Treatment Outcome
Triatoma - drug effects
Triatoma - growth & development
Triatoma infestans
Trypanosoma cruzi
Trypanosomiasis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chagas disease is the most important endemic disease in Latin America, mainly transmitted by Triatoma infestans in the Southern Cone countries of South America. Dogs are one of the main domestic reservoirs of Trypanosoma cruzi, the etiological agent of Chagas disease. The presence of dogs in rural households of endemic areas significantly increases the likelihood of the vectorial transmission of the parasite. We studied the mortality and blood intake of T. infestans exposed to dogs treated with different doses and formulations of fipronil. Two doses, two formulations, and different distances to the application point of fipronil were compared. Third instar nymphs of T. infestans were fed at different time intervals after the insecticide application up to 45 days post-application. No significant difference was found between the blood intake of nymphs fed on control and treated dogs with different doses and formulations ( p  > 0.05). The spray formulation showed lower effect and persistence than the spot-on formulation. The mortality rate caused by the spot-on formulation in the 26.8-mg active ingredient (a.i.)/kg dose was higher (48 %) than with the13.4-mg a.i./kg dose (25 %), 24 h after the insecticide application. The effect was highly heterogeneous among replicates of the same treatment. The mortality rate of nymphs fed over the point of the insecticide application was higher than the mortality of nymphs fed over places 12 cm apart from the fipronil application point, suggesting that the distribution of fipronil over the dog body is lower than the needed one to obtain a persistent triatomicide effect.
ISSN:0932-0113
1432-1955
DOI:10.1007/s00436-012-2979-6