Raccoonpoxvirus safety in immunocompromised and pregnant mouse models

Highlights • Raccoonpoxvirus is much safer than vaccinia virus (WR) in Nude and SCID mice. • Raccoonpoxvirus is much safer than vaccinia virus in pregnant mice. • Addition of rabies glycoprotein does not increase virulence of raccoonpoxvirus. • Raccoonpoxvirus does not persist in mouse organs. • Rem...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2014-06, Vol.32 (31), p.3977-3981
Main Authors: Jones, Gwendolyn J.B, Boles, Corey, Roper, Rachel L
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animal euthanasia
Animals
Antigens, Viral - immunology
Applied microbiology
Biological and medical sciences
Female
Fundamental and applied biological sciences. Psychology
Glycoproteins - immunology
Immunocompromised Host
Immunocompromised mice
Infections
Lymphocytes
Mammals
Mice
Mice, Inbred BALB C
Mice, Nude
Mice, SCID
Microbiology
Mouse model
Poxviridae
Poxvirus
Pregnancy
Rabies virus
Raccoonpox virus
Rodents
Safety
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccinia virus
Viral Envelope Proteins - immunology
Viral Vaccines - immunology
Virulence
Viruses
Zoonoses
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Raccoonpoxvirus is much safer than vaccinia virus (WR) in Nude and SCID mice. • Raccoonpoxvirus is much safer than vaccinia virus in pregnant mice. • Addition of rabies glycoprotein does not increase virulence of raccoonpoxvirus. • Raccoonpoxvirus does not persist in mouse organs. • Removal of thymidine kinase and hemagglutinin genes attenuates RCNV.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2014.05.018