Basaloid squamous cell carcinoma of the oral cavity: An analysis of 92 cases

Objectives/Hypothesis Basaloid squamous cell carcinoma (BSCC) is considered a rare and possibly more aggressive squamous cell carcinoma (SCC) variant. Until now, a series of exclusively oral cavity BSCC patients has not been previously reported. We endeavored to compare BSCC and SCC of the oral cavi...

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Bibliographic Details
Published in:The Laryngoscope 2014-07, Vol.124 (7), p.1573-1578
Main Authors: Fritsch, Valerie A., Gerry, Daniel R., Lentsch, Eric J.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Antineoplastic Agents - therapeutic use
Basaloid squamous cell carcinoma
Carcinoma, Basosquamous - diagnosis
Carcinoma, Basosquamous - therapy
Carcinoma, Squamous Cell - diagnosis
Carcinoma, Squamous Cell - therapy
Cervical cancer
Chemotherapy, Adjuvant
Disease-Free Survival
Female
Follow-Up Studies
Humans
Male
Medical prognosis
Medical research
Middle Aged
Mouth Neoplasms - diagnosis
Mouth Neoplasms - therapy
Neoplasm Staging
oral cavity
Prognosis
Prospective Studies
Radiosurgery - methods
SEER database
squamous cell carcinoma
Tomography, X-Ray Computed
Treatment Outcome
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Summary:Objectives/Hypothesis Basaloid squamous cell carcinoma (BSCC) is considered a rare and possibly more aggressive squamous cell carcinoma (SCC) variant. Until now, a series of exclusively oral cavity BSCC patients has not been previously reported. We endeavored to compare BSCC and SCC of the oral cavity, focusing on epidemiologic factors and survival outcomes. Study Design Retrospective analysis of population‐based data. Methods We compared epidemiologic factors, clinicopathologic data, and disease‐specific survivals (DSS) between 92 patients with oral cavity BSCC and 15,181 patients with SCC. Results High‐grade tumors and distant metastases were more common in the BSCC group (P ≤0.001). On multivariable analysis controlling for disease stage, BSCC patients had similar DSS to those with typical SCC (P = 0.231). Although there was a trend favoring definitive radiotherapy for BSCC, there were no significant differences in treatment approach between BSCC and SCC. The choice of treatment modality (radiation, surgery ± radiation) did not reveal a difference in DSS between the two tumor subtypes. Conclusion Analysis of the largest oral cavity BSCC series to date demonstrates that BSCC of the oral cavity carries a comparable prognosis to conventional‐type oral SCC. Level of Evidence 2b. Laryngoscope, 124:1573–1578, 2014
ISSN:0023-852X
1531-4995
DOI:10.1002/lary.24384