HLA-DR4 Subtype Frequencies in Rheumatoid Arthritis Indicate that DRB1 is the Major Susceptibility Locus within the HLA Class II Region

Susceptibility to rheumatoid arthritis (RA) may be due to the presence of shared functional epitopes common to the HLA-DR β chains of several RA-associated haplotypes. We have obtained direct evidence for this hypothesis by using the polymerase chain reaction and sequencing the DRB1 and DQB1 genes f...

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Bibliographic Details

Published in:	Proceedings of the National Academy of Sciences - PNAS 1989-12, Vol.86 (24), p.10049-10053
Main Authors:	Wordsworth, B. P., Lanchbury, J. S. S., Sakkas, L. I., Welsh, K. I., Panayi, G. S., Bell, J. I.
Format:	Article
Language:	eng
Subjects:	Alleles Antigens Arthritis, Rheumatoid - immunology Autoimmune diseases Base Sequence BASIC BIOLOGICAL SCIENCES BETA DECAY RADIOISOTOPES BETA-MINUS DECAY RADIOISOTOPES Binding sites Biological and medical sciences DAYS LIVING RADIOISOTOPES Disease Susceptibility DISEASES Diseases of the osteoarticular system DNA SEQUENCING Epitopes Epitopes - analysis GENE AMPLIFICATION GENES Genes, MHC Class II Genetic loci Haplotypes Histocompatibility Antigens Class II - genetics histocompatibility locus HLA HLA-DR Antigens - genetics HLA-DR4 Antigen - genetics Humans IMMUNOLOGY Inflammatory joint diseases ISOTOPES LIGHT NUCLEI Medical sciences Models, Molecular Molecular Sequence Data Molecules NUCLEI NUCLEIC ACIDS ODD-ODD NUCLEI Oligonucleotide Probes OLIGONUCLEOTIDES ORGANIC COMPOUNDS PATHOGENESIS PATIENTS PHOSPHORUS 32 PHOSPHORUS ISOTOPES Polymerase Chain Reaction Probability Protein Conformation RADIOISOTOPES RHEUMATIC DISEASES Rheumatoid arthritis Risk Factors SKELETAL DISEASES STRUCTURAL CHEMICAL ANALYSIS 550201 > Biochemistry-- Tracer Techniques
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