Distinct characteristics and new prognostic scoring system for Chinese patients with Waldenström macroglobulinemia

Waldenström macroglobulinemia (WM) is an uncommon lymphoid malignancy. The characteristics and prognosis of WM have never been systematically studied in the East. We analyzed the clinical characteristics and the prognostic factors of 90 Chinese WM patients, and compared them with the Western reports...

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Bibliographic Details
Published in:Chinese medical journal 2014, Vol.127 (12), p.2327-2331
Main Authors: Yi, Shuhua, Cui, Rui, Li, Zengjun, An, Gang, Qi, Junyuan, Zou, Dehui, Zhang, Peihong, Chen, Huishu, Wang, Jianxiang, Chang, Hong, Qiu, Lugui
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Female
Humans
Male
Middle Aged
Prognosis
Risk Factors
Waldenstrom Macroglobulinemia - diagnosis
Waldenstrom Macroglobulinemia - mortality
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Summary:Waldenström macroglobulinemia (WM) is an uncommon lymphoid malignancy. The characteristics and prognosis of WM have never been systematically studied in the East. We analyzed the clinical characteristics and the prognostic factors of 90 Chinese WM patients, and compared them with the Western reports. The median age was 62 years old with a male-to-female ratio of 3.74. The most common symptoms at diagnosis were fatigue (77.8%) and bleeding (20%), while only 6 patients (6.7%) were asymptomatic. In the univariate analysis, age >62 years, thrombocytopenia, leucopenia, cytopenias ≥ 2, and high risk on the international prognostic scoring system for WM were the adverse risk factors, but only age >62 years and ≥ 2 cytopenias were the independent prognostic factors in the multivariate analysis. Using age
ISSN:0366-6999
2542-5641
DOI:10.3760/cma.j.issn.0366-6999.20140120