BK Virus Encoded MicroRNAs Are Present in Blood of Renal Transplant Recipients With BK Viral Nephropathy

BK viral infection is an important cause of renal transplant dysfunction and failure. Current strategies utilize surveillance for infection with DNA polymerase chain reaction assays and modulation of immunosuppression. Many viruses including polyomaviruses encode microRNAs (miRNAs). We have detected...

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Bibliographic Details
Published in:American journal of transplantation 2014-05, Vol.14 (5), p.1183-1190
Main Authors: Li, J. Y. Z., McNicholas, K., Yong, T. Y., Rao, N., Coates, P. T. H., Higgins, G. D., Carroll, R. P., Woodman, R. J., Michael, M. Z., Gleadle, J. M.
Format: Article
Language:English
Subjects:
Biological and medical sciences
BK nephropathy
BK virus
BK Virus - genetics
BK Virus - isolation & purification
Blood
Case-Control Studies
DNA, Viral - genetics
Female
Follow-Up Studies
Gene Expression Regulation, Viral
Health risk assessment
Humans
Infectious diseases
Kidney Diseases - blood
Kidney Diseases - diagnosis
Kidney Diseases - virology
Kidney Transplantation
Male
Medical sciences
microRNA
MicroRNAs
MicroRNAs - blood
MicroRNAs - genetics
Middle Aged
Polymerase Chain Reaction
Polyomaviridae
Polyomavirus Infections - blood
Polyomavirus Infections - diagnosis
Polyomavirus Infections - virology
Prognosis
Real-Time Polymerase Chain Reaction
renal transplant
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger - genetics
RNA, Viral - blood
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Transplant Recipients
Transplants & implants
Viral diseases
Viral infections
Virus Replication
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Description
Summary:BK viral infection is an important cause of renal transplant dysfunction and failure. Current strategies utilize surveillance for infection with DNA polymerase chain reaction assays and modulation of immunosuppression. Many viruses including polyomaviruses encode microRNAs (miRNAs). We have detected BK virus (BKV) encoded miRNAs in the blood of infected renal transplant recipients, and see a strong correlation between BKV encoded miRNA and BKV DNA in blood and a relationship between levels of bkv‐miR‐B1‐5p and the presence of biopsy‐proven BK viral nephropathy. Further research is needed to determine whether the detection of this and other virally encoded miRNAs may be useful in the diagnosis of active viral replication. The investigators examine for BK virus encoded microRNAs in the blood of renal transplant recipients and detect these microRNAs in patients with active BK virus nephropathy.
ISSN:1600-6135
1600-6143
DOI:10.1111/ajt.12694