Quality of human spermatozoa: relationship between high-magnification sperm morphology and DNA integrity

Summary The aim of this work is to establish the relationship between the morphology of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI)‐selected spermatozoa and their DNA integrity. The 45 ejaculates were randomly distributed into three treatment groups: normozoospermic, oligoasthen...

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Bibliographic Details
Published in:Andrologia 2014-06, Vol.46 (5), p.547-555
Main Authors: Maettner, R., Sterzik, K., Isachenko, V., Strehler, E., Rahimi, G., Alabart, J. L., Sánchez, R., Mallmann, P., Isachenko, E.
Format: Article
Language:English
Subjects:
Adult
Apoptosis
DNA - metabolism
DNA Fragmentation
DNA integrity
human
Humans
Male
morphology
Sperm Motility
spermatozoa
Spermatozoa - metabolism
Spermatozoa - physiology
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Summary:Summary The aim of this work is to establish the relationship between the morphology of Intracytoplasmic Morphologically Selected Sperm Injection (IMSI)‐selected spermatozoa and their DNA integrity. The 45 ejaculates were randomly distributed into three treatment groups: normozoospermic, oligoasthenozoospermic and oligoasthenotheratozoospermic samples. The evaluation of DNA integrity was performed using the sperm chromatin dispersion test. It was established that DNA integrity of spermatozoa is strongly dependent on ejaculate quality (P  0.1). With decreased ejaculate quality, the percentage of spermatozoa with nonfragmented DNA decreased significantly (P 
ISSN:0303-4569
1439-0272
DOI:10.1111/and.12114