DNA repair XPCC1 and XPD genes polymorphism as associated with the development of bladder cancer and renal cell carcinoma

We examined the associations between the polymorphic alleles of the DNA repair genes XRCC1 (c.839G>A, rs25489; and c.1196A>G, rs25487), XPA (c.-4A>G, rs1800975), and XPD (c.2251A>C, rs13181) and the progression and severity of neoplasias in the urinary bladder and kidney in patients of t...

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Published in:Russian journal of genetics 2014-04, Vol.50 (4), p.421-429
Main Authors: Akhmadishina, L. Z., Gilyazova, I. R., Kutlyeva, L. R., Korytina, G. F., Kochetova, O. V., Urmantsev, M. F., Izmailova, S. M., Izmailov, A. A., Kunsbaeva, G. B., Zagidullin, A. A., Khaliullin, A. A., Pavlov, V. N., Victorova, T. V., Khusnutdinova, E. K.
Format: Article
Language:English
Subjects:
Animal Genetics and Genomics
Biomedical and Life Sciences
Biomedicine
Human Genetics
Microbial Genetics and Genomics
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Summary:We examined the associations between the polymorphic alleles of the DNA repair genes XRCC1 (c.839G>A, rs25489; and c.1196A>G, rs25487), XPA (c.-4A>G, rs1800975), and XPD (c.2251A>C, rs13181) and the progression and severity of neoplasias in the urinary bladder and kidney in patients of three distinct ethnic groups, Bashkir, Russians, and Tatar, residing in the Republic of Bashkorostan. The study enrolled 468 cancer patients and 351 healthy individuals. Genotyping for polymorphic alleles was carried out using the PCR-RFLP method. We identified an association between allele A of the c.839G>A locus of the XRCC1 gene and the incidence of the bladder cancer (BC) and renal cell carcinoma (RCC) in the Tatar study group, using the additive genetic effects model (Odds Ratio (OR) = 5.23 and OR = 3.90). In turn, the heterozygous G/A genotype frequency was significantly higher in the RCC patients of Bashkir ethnic origin, compared with the control group ( p = 0.0061, OR = 4.72). Additional analysis with consideration of participants smoking status showed that the G/A genotype is significantly more frequent in smokers with BC (OR = 1.96, p = 0.05) than in healthy smokers. We also determined, using the recessive genetic model, that the genotype A/A of the c.1196A>G locus of the XRCC1 gene was associated with a higher risk of BC in the Russian cohort (OR = 2.29, p = 0.0082) and an increased incidence of RCC in the Bashkir group (OR = 4.06, p = 0.05). A similar association was obtained for smokers. In contrast, the allele c.2251A>C in the XPD gene associated with a lower risk for BC and RCC in the Tatars ( p = 0.0003, OR = 0.48 and p < 0.0001, OR = 0.37) in the additive model and in the Bashkirs ( p = 0.0083, OR = 0.12) and Russians ( p = 0.0001, OR = 0.14) in the recessive model. Further, we uncovered that polymorphism c.839G>A in the XRCC1 gene contributes to the progression of noninvasive and invasive BC and promotes RCC at early and advanced stages of the disease. Thus, we identified similar associations between DNA repair gene polymorphisms and the incidence and progression of BC and RCC. We propose that this result points to the involvement of common pathogenetic mechanisms in the initiation and progression of the urinary neoplasias.
ISSN:1022-7954
1608-3369
DOI:10.1134/S1022795414040024