Adiponectin gene variants and the risk of coronary heart disease: a 16-year longitudinal study

ObjectiveCirculating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the...

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Published in:European journal of endocrinology 2014-07, Vol.171 (1), p.107-115
Main Authors: Cheung, Chloe Y Y, Hui, Elaine Y L, Cheung, Bernard M Y, Woo, Y C, Xu, Aimin, Fong, Carol H Y, Ong, K L, Yeung, C Y, Janus, Edward D, Tse, Hung-Fat, Sham, Pak C, Lam, Karen S L
Format: Article
Language:English
Subjects:
Adiponectin - blood
Adiponectin - genetics
Adult
Biological and medical sciences
Cardiology. Vascular system
Clinical Study
Coronary Artery Disease - blood
Coronary Artery Disease - genetics
Coronary heart disease
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Genetic Predisposition to Disease
Heart
Humans
Longitudinal Studies
Male
Medical sciences
Middle Aged
Polymorphism, Single Nucleotide - genetics
Vertebrates: endocrinology
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Summary:ObjectiveCirculating adiponectin levels have been shown to be associated with a risk of coronary heart disease (CHD). However, its primary role in protecting against the development of CHD remains controversial due to conflicting observations in prospective studies. To gain further insight into the primary role of adiponectin, our major objective was to investigate the relationship between single nucleotide polymorphisms (SNPs) of the adiponectin gene (ADIPOQ) and incident CHD in a population-based cohort with no CHD at baseline.Design and methodsWe conducted a 16-year longitudinal study in 2196 subjects from the Hong Kong Cardiovascular Risk Factor Prevalence Study (CRISPS). During 33 862 person-years of follow-up, 184 subjects developed CHD (cumulative incidence rate=5.4 per 1000 person-years). Nine ADIPOQ SNPs with potential functional relevance or shown to be associated with adiponectin levels and/or CHD were genotyped.ResultsAmong the nine ADIPOQ SNPs, +276G>T (rs1501299) was independently associated with incident CHD in men but not in women, even after adjustments for traditional cardiovascular risk factors (Padjusted=5.5×10−3 to 0.023; hazard ratio=1.39–1.54). Furthermore, there was a significant association of the T allele of +276G>T with a lower adiponectin level (P=0.027; β (95% CI)=−0.05 (−0.10, −0.01).ConclusionsThis study demonstrated that +276G>T may be an independent predictor of CHD development. Our findings suggest that low adiponectin levels, as may be influenced by +276G>T, confer a higher risk of CHD, in keeping with a role of hypoadiponectinaemia in the development of CHD in the general population.
ISSN:0804-4643
1479-683X
DOI:10.1530/EJE-14-0079