New classification of directly compressible (DC) excipients in function of the SeDeM Diagarm Expert System

As a methodology for characterizing substances with regard to its viability in direct compression, the SeDeM Diagram Expert System may be considered a new tool in terms of the number of parameters applied and its optimization. The paper is based on the experimental SeDeM characterization study of 51...

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Bibliographic Details
Published in:International journal of pharmaceutics 2014-08, Vol.470 (1-2), p.15-27
Main Authors: Suñé-Negre, Josep M., Roig, Manel, Fuster, Roser, Hernández, Carmen, Ruhí, Ramon, García-Montoya, Encarna, Pérez-Lozano, Pilar, Miñarro, Montserrat, Ticó, Josep R.
Format: Article
Language:English
Subjects:
Compressive Strength
Direct compression (DC)
Excipients - chemistry
Excipients - classification
Expert Systems
Good compression index (IGC)
Optimal DC excipient
Particle Size
Porosity
Rheology
SeDeM
Tablet excipient
Tablet preformulation
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Summary:As a methodology for characterizing substances with regard to its viability in direct compression, the SeDeM Diagram Expert System may be considered a new tool in terms of the number of parameters applied and its optimization. The paper is based on the experimental SeDeM characterization study of 51 directly compressible (DC) excipients. After selecting the parameters, and comparing the corresponding results, the choices available within the SeDeM Expert System could be expanded. Through applied variants, the maximum and optimal values of the DC diluent excipient were precisely defined and the mathematical limits of the parameters, functions and parametric indices that define the level of direct compressibility were established. These studies have allowed us to propose a new classification of excipients CD based on its rheological and compressibility capability, resulting in a periodic table of CD excipients. It has been determined that the best excipient for direct compression should have an index of good compression (IGC) of 8.832.
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2014.04.068