Data-mining for sulfur and fluorine: an evaluation of pharmaceuticals to reveal opportunities for drug design and discovery

Among carbon, hydrogen, oxygen, and nitrogen, sulfur and fluorine are both leading constituents of the pharmaceuticals that comprise our medicinal history. In efforts to stimulate the minds of both the general public and expert scientist, statistics were collected from the trends associated with the...

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Bibliographic Details
Published in:Journal of medicinal chemistry 2014-04, Vol.57 (7), p.2832-2842
Main Authors: Ilardi, Elizabeth A, Vitaku, Edon, Njardarson, Jon T
Format: Article
Language:English
Subjects:
Animals
Data Mining
Drug Approval
Drug Design
Drug Discovery
Evaluation Studies as Topic
Fluorine - chemistry
Humans
Pharmaceutical Preparations - chemistry
Sulfur - chemistry
United States
United States Food and Drug Administration
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Summary:Among carbon, hydrogen, oxygen, and nitrogen, sulfur and fluorine are both leading constituents of the pharmaceuticals that comprise our medicinal history. In efforts to stimulate the minds of both the general public and expert scientist, statistics were collected from the trends associated with therapeutics spanning 12 disease categories (a total of 1969 drugs) from our new graphical montage compilation: disease focused pharmaceuticals posters. Each poster is a vibrant display of a collection of pharmaceuticals (including structural image, Food and Drug Administration (FDA) approval date, international nonproprietary name (INN), initial market name, and a color-coded subclass of function) organized chronologically and classified according to an association with a particular clinical indication. Specifically, the evolution and structural diversity of sulfur and the popular integration of fluorine into drugs introduced over the past 50 years are evaluated. The presented qualitative conclusions in this article aim to promote innovative insights into drug development.
ISSN:1520-4804
DOI:10.1021/jm401375q