Evidence for reduced neuromuscular function in men with a history of androgen deprivation therapy for prostate cancer

Summary Background Indices of body composition and muscular strength were compared between men with prostate cancer (PCa) treated with androgen deprivation therapy (ADT) and asymptomatic matched men. Methods Nine subjects aged 63–83 years with PCa who received ADT (PCa+ADT; duration 6–180 months) an...

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Bibliographic Details
Published in:Clinical physiology and functional imaging 2014-05, Vol.34 (3), p.209-217
Main Authors: Girard, Danielle, Marino, Frank E., Cannon, Jack
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Androgen Antagonists - adverse effects
Antigens
Antineoplastic Agents, Hormonal - adverse effects
Biomechanical Phenomena
Body Composition - drug effects
Cancer
Case-Control Studies
Cross-Sectional Studies
Deprivation
Humans
Kallikreins - blood
lean muscle mass
Male
Medical research
Men
Middle Aged
muscle quality
muscle strength
Muscle Strength - drug effects
Muscle, Skeletal - drug effects
Muscle, Skeletal - pathology
Muscle, Skeletal - physiopathology
Muscular strength
Muscular system
neuromuscular mechanisms
normalized peak torque
peak torque
Prostate
Prostate cancer
Prostate-Specific Antigen - blood
Prostatic Neoplasms - blood
Prostatic Neoplasms - drug therapy
Strength
Testosterone - blood
Therapy
Torque
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Summary:Summary Background Indices of body composition and muscular strength were compared between men with prostate cancer (PCa) treated with androgen deprivation therapy (ADT) and asymptomatic matched men. Methods Nine subjects aged 63–83 years with PCa who received ADT (PCa+ADT; duration 6–180 months) and 11 asymptomatic aged‐matched eugonadal men (HM) aged 59–80 years were assessed for prostate‐specific antigen (PSA) and total testosterone (TT). Total body non‐osseous lean mass (TBLM) and right thigh non‐osseous fat‐free mass (RTLM) were assessed using dual‐energy X‐ray absorptiometry. Peak torque of the right knee extensors at 0° s−1 (ISO) and 60° s−1 (CON), maximal handgrip strength of the dominant hand (MHS) and whole‐body strength (WBS) were assessed. ISO and CON per unit mass of RTLM and MHS and WBS per unit mass of TBLM were calculated. Results Age, height, mass, body mass index and prostate‐specific antigen were comparable between groups (P>0·05), while TT was lower in PCa+ADT (P
ISSN:1475-0961
1475-097X
DOI:10.1111/cpf.12084