Oligodendrogliomas with Abundant Refractile Eosinophilic Granular Cells

Refractile eosinophilic granular cells, when present in abundance in a glioma, may trigger a diagnosis of the relatively familiar and inherently malignant 'granular cell astrocytoma'. The following two cases remind us that refractile eosinophilic granular cells are not unique to granular c...

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Bibliographic Details
Published in:Canadian journal of neurological sciences 2013-09, Vol.40 (5), p.746-748
Main Authors: Au, Kelvin, Bilbao, Juan, Mainprize, Todd, Schwartz, Michael, Keith, Julia
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Brain Neoplasms - pathology
Brief Communications
Cytoplasmic Granules - pathology
Development. Senescence. Regeneration. Transplantation
Eosinophils - pathology
Female
Fundamental and applied biological sciences. Psychology
Humans
Magnetic Resonance Imaging
Male
Medical sciences
Middle Aged
Nerve Tissue Proteins - metabolism
Neurology
Oligodendroglioma - pathology
Vertebrates: nervous system and sense organs
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Summary:Refractile eosinophilic granular cells, when present in abundance in a glioma, may trigger a diagnosis of the relatively familiar and inherently malignant 'granular cell astrocytoma'. The following two cases remind us that refractile eosinophilic granular cells are not unique to granular cell astrocytoma but can also dominate the histology of oligodendroglioma confirmed by 1p19q loss, and the immunohistochemical and ultrastructural features of two such cases are reviewed. Refractile eosinophilic granular cells are not to be confused with the similar sounding term of eosinophilic granular bodies, the hyaline PAS positive accumulations frequenting low grade glial and glioneuronal tumours.
ISSN:0317-1671
2057-0155
DOI:10.1017/S0317167100015067