Red Wine and Oenological Extracts Display Antimicrobial Effects in an Oral Bacteria Biofilm Model

The antimicrobial effects of red wine and its inherent components on oral microbiota were studied by using a 5-species biofilm model of the supragingival plaque that includes Actinomyces oris, Fusobacterium nucleatum, Streptococcus oralis, Streptococcus mutans and Veillonella dispar. Microbiological...

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Bibliographic Details
Published in:Journal of agricultural and food chemistry 2014-05, Vol.62 (20), p.4731-4737
Main Authors: Muñoz-González, Irene, Thurnheer, Thomas, Bartolomé, Begoña, Moreno-Arribas, M. Victoria
Format: Article
Language:English
Subjects:
Actinomyces - drug effects
Actinomyces - physiology
Anti-Bacterial Agents - pharmacology
anti-infective properties
bacteria
biofilm
Biofilms - drug effects
Color
confocal laser scanning microscopy
Dental Plaque - microbiology
Fusobacterium nucleatum
Fusobacterium nucleatum - drug effects
Fusobacterium nucleatum - physiology
grape seeds
Humans
Plant Extracts - pharmacology
procyanidins
red wines
seed extracts
Streptococcus - drug effects
Streptococcus - physiology
Streptococcus mutans
Streptococcus oralis
Veillonella - drug effects
Veillonella - physiology
Veillonella dispar
Vitis - chemistry
Wine - analysis
yeasts
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Summary:The antimicrobial effects of red wine and its inherent components on oral microbiota were studied by using a 5-species biofilm model of the supragingival plaque that includes Actinomyces oris, Fusobacterium nucleatum, Streptococcus oralis, Streptococcus mutans and Veillonella dispar. Microbiological analysis (CFU counting and confocal laser scanning microscopy) of the biofilms after the application of red wine, dealcoholized red wine, and red wine extract solutions spiked or not with grape seed and inactive dry yeast extracts showed that the solutions spiked with seed extract were effective against F. nucleatum, S. oralis and A. oris. Also, red wine and dealcoholized wine had an antimicrobial effect against F. nucleatum and S. oralis. Additional experiments showed almost complete and early degradation of flavan-3-ol precursors [(+)-catechin and procyanidin B2] when incubating biofilms with the red wine extract. To our knowledge, this is the first study of antimicrobial properties of wine in an oral biofilm model.
ISSN:0021-8561
1520-5118
DOI:10.1021/jf501768p