Analysis of risk factors for recurrence after curative resection of well-differentiated pancreatic neuroendocrine tumors based on the new grading classification

Background It is difficult to predict the malignant potential of pancreatic neuroendocrine tumors (PNETs) precisely. This study investigated the validity of a new grading system adopted by the World Health Organization 2010 classification to determine risk factors for recurrence of PNETs. Methods Da...

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Bibliographic Details
Published in:Journal of hepato-biliary-pancreatic sciences 2014-06, Vol.21 (6), p.418-425
Main Authors: Tsutsumi, Kosuke, Ohtsuka, Takao, Fujino, Minoru, Nakashima, Hiroshi, Aishima, Shinichi, Ueda, Junji, Takahata, Shunichi, Nakamura, Masafumi, Oda, Yoshinao, Tanaka, Masao
Format: Article
Language:English
Subjects:
Adult
Aged
Analysis of Variance
Classification
Cohort Studies
Confidence Intervals
Disease-Free Survival
Female
Grading classification
Humans
Japan
Male
Metastasis
Middle Aged
Multivariate Analysis
Neoplasm Grading - classification
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - mortality
Neoplasm Recurrence, Local - pathology
Neural invasion
Neuroendocrine Tumors - mortality
Neuroendocrine Tumors - pathology
Neuroendocrine Tumors - surgery
Pancreatic Neoplasms - mortality
Pancreatic Neoplasms - pathology
Pancreatic Neoplasms - surgery
Pancreatic neuroendocrine tumor
Predictive Value of Tests
Predictors of recurrence
Prognosis
Proportional Hazards Models
Reproducibility of Results
Retrospective Studies
Risk Factors
Survival Rate
Treatment Outcome
Tumors
WHO 2010 classification
World Health Organization
Young Adult
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Summary:Background It is difficult to predict the malignant potential of pancreatic neuroendocrine tumors (PNETs) precisely. This study investigated the validity of a new grading system adopted by the World Health Organization 2010 classification to determine risk factors for recurrence of PNETs. Methods Data of 70 patients with PNETs who underwent curative resection were retrospectively examined by uni‐ and multivariate analyses. Histopathological findings were re‐reviewed by experienced pathologists. NET G1 was defined as mitotic count 
ISSN:1868-6974
1868-6982
DOI:10.1002/jhbp.47