The induction of growth-altered cell populations (tumor-initiation sites) in rat tracheal implants exposed to benzo[a]pyrene and formaldehyde

The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumorinitiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 month...

Full description

Saved in:
Bibliographic Details
Published in:Carcinogenesis (New York) 1987-12, Vol.8 (12), p.1951-1953
Main Authors: Cosma, G.N., Marchok, A.C.
Format: Article
Language:English
Subjects:
Animals
Applied sciences
Benzo(a)pyrene
Cell Division
Cell Transformation, Neoplastic
Cocarcinogenesis
Exact sciences and technology
Formaldehyde
Other techniques and industries
Rats
Tracheal Neoplasms - chemically induced
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of exposure to benzo[a]pyrene (BAP) and formaldehyde (HCHO), alone and combined, on the induction of carcinogenesis in rat tracheal implants was determined as the number of growth-altered cell populations (tumorinitiation sites, TIS) per trachea. While exposure twice-weekly for 4.5 months to 0.2% HCHO solution gave only a weak response (0.25 TIS/trachea), 2.37 TIS per trachea were detected after exposure to 20 μg BAP in the same regimen. The combination of BAP followed by HCHO had a greater response than either agent alone (7.83 TIS/trachea), while the reverse exposure gave 1.49 TIS per trachea, which was less than BAP alone. Thus, the induction of TIS by combined exposure to HAP and HCHO was dependent on the order of exposure, and could not be predicted from their individual exposures.
ISSN:0143-3334
1460-2180
DOI:10.1093/carcin/8.12.1951