A new carbohydrate-based wound dressing fibre with superior absorption and antimicrobial potency

•Discusses introduction of a new polysaccharide material i.e. Psyllium into alginate.•Examine absorption of the new fibre against commercial wound dressing products.•Identifies superior absorptions of saline and solution A compared to test fibres.•Examines effect of silver carbonate as a fibre compo...

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Bibliographic Details
Published in:Carbohydrate polymers 2014-01, Vol.101, p.1184-1190
Main Authors: Miraftab, M., Masood, R., Edward-Jones, V.
Format: Article
Language:English
Subjects:
Absorption
Alginates - chemistry
Anti-Infective Agents - chemistry
Anti-Infective Agents - pharmacology
Applied sciences
Bandages - microbiology
Biological and medical sciences
Carbohydrate Sequence
Dressing
Escherichia coli - drug effects
Exact sciences and technology
Fibers and threads
Forms of application and semi-finished materials
Gels
Glucuronic Acid - chemistry
Hexuronic Acids - chemistry
Hybrid
Medical sciences
Molecular Sequence Data
Polymer industry, paints, wood
Polysaccharides - chemistry
Polysaccharides - pharmacology
Psyllium
Psyllium - chemistry
Silver
Silver - chemistry
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Technology of polymers
Technology. Biomaterials. Equipments
Wound Healing
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Summary:•Discusses introduction of a new polysaccharide material i.e. Psyllium into alginate.•Examine absorption of the new fibre against commercial wound dressing products.•Identifies superior absorptions of saline and solution A compared to test fibres.•Examines effect of silver carbonate as a fibre component on bacteria including MRSA.•Superior antimicrobial behaviour with a lot less silver and shorter action time. Heavily exudating wounds can lead to infection and unnecessary trauma if they are not adequately managed. Manufacturers involved in production and marketing of high absorption silver dressings, besides emphasising high absorptions of their dressings are keen to highlight potent antimicrobial abilities of their products against all kinds of pathogens including MRSA. However, there are little or no credible reports on minimal but potent quantities of silver needed in a dressing to eliminate bacteria spread and growth or how effectively the silver within a dressing is released over time. This paper introduces a new hybrid biomaterial fibre made from polysaccharide-based polymers with inbuilt ability to gel and absorb large quantities of pseudo exudates. Furthermore, it will be reported that the new fibre carries up to six times less silver than it is conventionally used in silver dressings and displays a very slow rate of release whilst maintaining full potency over time against known Gram positive, Gram negative micro-organisms including MRSA. The paper concludes that the developed hybrid fibre has long lasting antimicrobial and gelling properties comparable, if not better, than Acticoat AA and Aquacel Ag, two commercially available silver dressings.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2013.10.058