Form follows function — the three-dimensional structure of antigen receptor gene loci

Highlights • The spatial conformation of antigen receptor gene loci directs V(D)J recombination. • V(D)J recombination co-opted DNA looping as a mode of regulation. • The sequence elements directing IGH locus structures arose gradually during evolution.

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Bibliographic Details
Published in:Current opinion in immunology 2014-04, Vol.27, p.33-37
Main Author: Fugmann, Sebastian D
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Genetic Loci
Humans
Immunoglobulins - genetics
Immunoglobulins - immunology
Nucleic Acid Conformation
Receptors, Antigen - chemistry
Receptors, Antigen - genetics
Receptors, Antigen - immunology
V(D)J Recombination
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Description
Summary:Highlights • The spatial conformation of antigen receptor gene loci directs V(D)J recombination. • V(D)J recombination co-opted DNA looping as a mode of regulation. • The sequence elements directing IGH locus structures arose gradually during evolution.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2014.01.011