Method for the synthesis of N-alkyl-O-alkyl carbamates

Primary and secondary carbamates were prepared from primary, secondary and neo-pentyl alcohols, and carbonyl-di-imidazole (CDI), using a new three step method. Non-acidic alcohols reacted with CDI affording carbamoyl-imidazoles with excellent yields (92–97%). The carbamoyl-imidazoles were then conve...

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Bibliographic Details
Published in:RSC advances 2014-01, Vol.4 (25), p.13012-13017
Main Authors: Vaillard, Victoria A., González, Marianela, Perotti, Jesica P., Grau, Ricardo J. A., Vaillard, Santiago E.
Format: Article
Language:English
Subjects:
Alcohols
Amines
Carbonyls
Synthesis
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Summary:Primary and secondary carbamates were prepared from primary, secondary and neo-pentyl alcohols, and carbonyl-di-imidazole (CDI), using a new three step method. Non-acidic alcohols reacted with CDI affording carbamoyl-imidazoles with excellent yields (92–97%). The carbamoyl-imidazoles were then converted into the more reactive imidazolium salts, which upon reaction with primary and secondary amines afforded the corresponding carbamates in high isolated yields (66–99%).
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA00373J