Properties of amorphous silica nanoparticles colloid drug delivery system synthesized using the micelle formation method

This study describes the formation and properties of a silica nanocolloid drug delivery system synthesized using micelle formation method. Previously, we have reported feasibility of using the same approach to entrap colorless water soluble drug (isoniazid). However, the entrapment of the drug insid...

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Bibliographic Details
Published in:Journal of nanoparticle research : an interdisciplinary forum for nanoscale science and technology 2014-02, Vol.16 (2), p.1-14, Article 2256
Main Authors: Ab Wab, Hajarul Azwana, Abdul Razak, Khairunisak, Zakaria, Nor Dyana
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Characterization and Evaluation of Materials
Chemistry and Materials Science
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Fundamental and applied biological sciences. Psychology
Inorganic Chemistry
Lasers
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Materials Science
Methods. Procedures. Technologies
Nanocrystalline materials
Nanoparticles
Nanoscale materials and structures: fabrication and characterization
Nanotechnology
Optical Devices
Optics
Others
Photonics
Physical Chemistry
Physics
Research Paper
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Various methods and equipments
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Summary:This study describes the formation and properties of a silica nanocolloid drug delivery system synthesized using micelle formation method. Previously, we have reported feasibility of using the same approach to entrap colorless water soluble drug (isoniazid). However, the entrapment of the drug inside nanoparticles (NPs) could not be observed due to its colorless nature. In this study, poor water soluble Rifampicin (RIF) was used as a drug model. Orange color of RIF enables observation and measurement using UV–Vis spectrophotometer. Several parameters were systematically studied: reaction temperature (25–70 °C) produced 28–97 nm, amount of surfactant (4–9 g) produced 44–66 nm, butanol volume (6–18 ml) produced 50–157 nm, and drug concentration. Particle size could be tuned from 28 to 157 nm by varying synthesis parameters. NP size was highly influenced by reaction temperature and butanol. Silica nanocolloid-entrapped RIF (50 and 70 nm SiRif) were synthesized and further analyzed for biological application. The stability of SiRif in biological media, such as in 0.1, 0.5, and 1.0 M NaCl solution and 5, 10, and 25 % mouse serum, was examined. RIF was successfully entrapped inside silica nanocolloids. Moreover, 50 and 70 nm SiRif exhibited almost similar stability in NaCl and mouse serum. The drug release profiles in 0.1 and 1.0 mM phosphate buffer solutions and different pH at 37 °C were examined for several days. Results indicate that 70 nm SiRif had higher drug loading and slower release profile than 50 nm SiRif. 70 nm SiRif was optimally released at pH 6.8.
ISSN:1388-0764
1572-896X
DOI:10.1007/s11051-014-2256-y