Causal relationship between the AHSG gene and BMD through fetuin-A and BMI: multiple mediation analysis

Summary Using mediation analysis, a causal relationship between the AHSG gene and bone mineral density (BMD) through fetuin-A and body mass index (BMI) mediators was suggested. Introduction Fetuin-A, a multifunctional protein of hepatic origin, is associated with bone mineral density. It is unclear...

Full description

Saved in:
Bibliographic Details
Published in:Osteoporosis international 2014-05, Vol.25 (5), p.1555-1562
Main Authors: Sritara, C., Thakkinstian, A., Ongphiphadhanakul, B., Chailurkit, L., Chanprasertyothin, S., Ratanachaiwong, W., Vathesatogkit, P., Sritara, P.
Format: Article
Language:English
Subjects:
Absorptiometry, Photon - methods
Adult
alpha-2-HS-Glycoprotein - analysis
alpha-2-HS-Glycoprotein - genetics
alpha-2-HS-Glycoprotein - physiology
Body Mass Index
Bone density
Bone Density - genetics
Bone Density - physiology
Cross-Sectional Studies
Endocrinology
Female
Genes
Genetic Association Studies
Genotype
Glycoproteins
Hip Joint - physiology
Humans
Lumbar Vertebrae - physiology
Male
Medicine
Medicine & Public Health
Middle Aged
Motor Activity - physiology
Original Article
Orthopedics
Osteoporosis
Rheumatology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Summary Using mediation analysis, a causal relationship between the AHSG gene and bone mineral density (BMD) through fetuin-A and body mass index (BMI) mediators was suggested. Introduction Fetuin-A, a multifunctional protein of hepatic origin, is associated with bone mineral density. It is unclear if this association is causal. This study aimed at clarification of this issue. Methods A cross-sectional study was conducted among 1,741 healthy workers from the Electricity Generating Authority of Thailand (EGAT) cohort. The alpha-2-Heremans–Schmid glycoprotein ( AHSG ) rs2248690 gene was genotyped. Three mediation models were constructed using seemingly unrelated regression analysis. First, the ln[fetuin-A] group was regressed on the AHSG gene. Second, the BMI group was regressed on the AHSG gene and the ln[fetuin-A] group. Finally, the BMD model was constructed by fitting BMD on two mediators (ln[fetuin-A] and BMI) and the independent AHSG variable. All three analyses were adjusted for confounders. Results The prevalence of the minor T allele for the AHSG locus was 15.2 %. The AHSG locus was highly related to serum fetuin-A levels ( P  
ISSN:0937-941X
1433-2965
DOI:10.1007/s00198-014-2634-4